{"id":523,"date":"2026-05-19T20:42:11","date_gmt":"2026-05-19T17:42:11","guid":{"rendered":"https:\/\/novolakrb1.ru\/statii\/?page_id=523"},"modified":"2026-05-20T09:37:53","modified_gmt":"2026-05-20T06:37:53","slug":"tight-junctions-kishechnik","status":"publish","type":"page","link":"https:\/\/novolakrb1.ru\/statii\/tight-junctions-kishechnik\/","title":{"rendered":"\u0422\u0435\u0441\u043d\u044b\u0435 \u043a\u043e\u043d\u0442\u0430\u043a\u0442\u044b"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"523\" class=\"elementor elementor-523\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-30a2ad45 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"30a2ad45\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3a058663\" data-id=\"3a058663\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2bd2bb62 elementor-widget elementor-widget-heading\" data-id=\"2bd2bb62\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">\u0422\u0435\u0441\u043d\u044b\u0435 \u043c\u0435\u0436\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u044b\u0435 \u043a\u043e\u043d\u0442\u0430\u043a\u0442\u044b (Tight Junctions): \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u044b\u0439 \u0440\u0430\u0437\u0431\u043e\u0440 \u0438 \u0434\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0435 \u043c\u0435\u0442\u043e\u0434\u044b \u0432\u043e\u0441\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u0438\u044f<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-29bcf544 elementor-widget elementor-widget-text-editor\" data-id=\"29bcf544\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-size: 13px; color: #64748b; margin: 0 0 24px 0;\"><a style=\"color: #3b82f6; text-decoration: none;\" href=\"\/\">\u0413\u043b\u0430\u0432\u043d\u0430\u044f<\/a> \u203a <a style=\"color: #3b82f6; text-decoration: none;\" href=\"https:\/\/novolakrb1.ru\/statii\/zdorove-kishechnika\/\">\u0417\u0434\u043e\u0440\u043e\u0432\u044c\u0435 \u043a\u0438\u0448\u0435\u0447\u043d\u0438\u043a\u0430<\/a> \u203a <a style=\"color: #3b82f6; text-decoration: none;\" href=\"https:\/\/novolakrb1.ru\/statii\/dyravyy-kishechnik\/\">\u0414\u044b\u0440\u044f\u0432\u044b\u0439 \u043a\u0438\u0448\u0435\u0447\u043d\u0438\u043a<\/a> \u203a <span style=\"color: #64748b;\">Tight Junctions<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dbef7e2 elementor-widget elementor-widget-text-editor\" data-id=\"dbef7e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-size:17px;line-height:1.75;color:#1E293B;font-weight:500;margin:0 0 14px 0;\">Tight junctions (\u0442\u0435\u0441\u043d\u044b\u0435 \u043c\u0435\u0436\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u044b\u0435 \u043a\u043e\u043d\u0442\u0430\u043a\u0442\u044b, \u0422\u041c\u041a) \u2014 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u044b\u0435 \u00ab\u0437\u0430\u043c\u043a\u0438\u00bb \u043c\u0435\u0436\u0434\u0443 \u043a\u043b\u0435\u0442\u043a\u0430\u043c\u0438 \u043a\u0438\u0448\u0435\u0447\u043d\u043e\u0433\u043e \u044d\u043f\u0438\u0442\u0435\u043b\u0438\u044f. \u0418\u043c\u0435\u043d\u043d\u043e \u0438\u0445 \u043f\u043e\u0432\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u0435 \u043b\u0435\u0436\u0438\u0442 \u0432 \u043e\u0441\u043d\u043e\u0432\u0435 \u0441\u0438\u043d\u0434\u0440\u043e\u043c\u0430 \u0434\u044b\u0440\u044f\u0432\u043e\u0433\u043e \u043a\u0438\u0448\u0435\u0447\u043d\u0438\u043a\u0430. \u041d\u0430 \u044d\u0442\u043e\u0439 \u0441\u0442\u0440\u0430\u043d\u0438\u0446\u0435 \u2014 \u0434\u0435\u0442\u0430\u043b\u044c\u043d\u044b\u0439 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u044b\u0439 \u0440\u0430\u0437\u0431\u043e\u0440: \u0447\u0442\u043e \u0442\u0430\u043a\u043e\u0435 ZO-1, \u043e\u043a\u043a\u043b\u044e\u0434\u0438\u043d \u0438 \u043a\u043b\u0430\u0443\u0434\u0438\u043d\u044b, \u043a\u0430\u043a\u0438\u0435 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044b \u0438\u0445 \u0440\u0430\u0437\u0440\u0443\u0448\u0430\u044e\u0442 \u0438 \u043a\u0430\u043a\u0438\u0435 \u043d\u0443\u0442\u0440\u0438\u0435\u043d\u0442\u044b \u0434\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c\u043d\u043e \u0432\u043e\u0441\u0441\u0442\u0430\u043d\u0430\u0432\u043b\u0438\u0432\u0430\u044e\u0442 \u0431\u0430\u0440\u044c\u0435\u0440.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3bb076c6 elementor-widget elementor-widget-text-editor\" data-id=\"3bb076c6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"background: #F0F9FF; border: 1px solid #BAE6FD; border-radius: 8px; padding: 12px 18px; margin-bottom: 10px;\"><p><span style=\"color: #0284c7; font-size: 15px; font-weight: 600;\">\u2192<\/span><a style=\"color: #0284c7; font-size: 15px; font-weight: 600; text-decoration: none;\" href=\"https:\/\/novolakrb1.ru\/statii\/dyravyy-kishechnik\/\">\u2190 \u0413\u043b\u0430\u0432\u043d\u0430\u044f \u0441\u0442\u0440\u0430\u043d\u0438\u0446\u0430 \u043a\u043b\u0430\u0441\u0442\u0435\u0440\u0430: \u0414\u044b\u0440\u044f\u0432\u044b\u0439 \u043a\u0438\u0448\u0435\u0447\u043d\u0438\u043a \u2014 \u043f\u043e\u043b\u043d\u044b\u0439 \u0433\u0438\u0434 2026<\/a><\/p><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-46f0f091 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"46f0f091\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-267b8217\" data-id=\"267b8217\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-69ef9e8b elementor-widget elementor-widget-text-editor\" data-id=\"69ef9e8b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-size:11px;font-weight:700;letter-spacing:2px;text-transform:uppercase;color:#64748B;margin:0 0 10px 0;\">\u0421\u043e\u0434\u0435\u0440\u0436\u0430\u043d\u0438\u0435<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-23febc2 elementor-widget elementor-widget-text-editor\" data-id=\"23febc2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"background:#EFF6FF;border-left:4px solid #1E40AF;border-radius:0 8px 8px 0;padding:16px 20px;margin-bottom:16px;\"><ol style=\"padding-left:20px;margin:0;font-size:15px;line-height:2;color:#1E293B;\"><li>\u041c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u0430\u044f \u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u0430 tight junctions \u2014 \u0442\u0440\u0438 \u0443\u0440\u043e\u0432\u043d\u044f \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u0430\u0446\u0438\u0438<\/li>\n      <li>\u0424\u0443\u043d\u043a\u0446\u0438\u0438 TJ: \u0431\u0430\u0440\u044c\u0435\u0440, \u043f\u043e\u043b\u044f\u0440\u043d\u043e\u0441\u0442\u044c, \u0438\u043c\u043c\u0443\u043d\u043d\u0430\u044f \u0441\u0438\u0433\u043d\u0430\u043b\u0438\u0437\u0430\u0446\u0438\u044f<\/li>\n      <li>\u0427\u0442\u043e \u0440\u0430\u0437\u0440\u0443\u0448\u0430\u0435\u0442 TJ \u2014 \u0442\u0430\u0431\u043b\u0438\u0446\u0430 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u044b\u0445 \u043c\u0438\u0448\u0435\u043d\u0435\u0439 \u0438 \u0442\u0440\u0438\u0433\u0433\u0435\u0440\u043e\u0432<\/li>\n      <li>MLCK-\u0437\u0430\u0432\u0438\u0441\u0438\u043c\u044b\u0439 \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c \u043e\u0442\u043a\u0440\u044b\u0442\u0438\u044f TJ \u2014 \u043a\u043b\u044e\u0447\u0435\u0432\u043e\u0439 \u043f\u0443\u0442\u044c<\/li>\n      <li>\u041d\u0443\u0442\u0440\u0438\u0446\u0435\u0432\u0442\u0438\u043a\u0438 \u0434\u043b\u044f \u0432\u043e\u0441\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u0438\u044f TJ \u2014 \u043f\u043e\u043b\u043d\u0430\u044f \u0442\u0430\u0431\u043b\u0438\u0446\u0430 \u0441 \u0434\u043e\u0437\u0430\u043c\u0438<\/li>\n      <li>\u041f\u0440\u043e\u0442\u043e\u043a\u043e\u043b \u0432\u043e\u0441\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u0438\u044f \u2014 \u043f\u043e\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u044c \u0438 \u043c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433<\/li>\n      <li>\u041f\u0435\u0440\u0441\u043f\u0435\u043a\u0442\u0438\u0432\u043d\u044b\u0435 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044b (\u0431\u0443\u0434\u0443\u0449\u0435\u0435 \u0442\u0435\u0440\u0430\u043f\u0438\u0438)<\/li>\n      <li>FAQ<\/ol><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5e0b7449 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5e0b7449\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-728009a8\" data-id=\"728009a8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-39a07966 elementor-widget elementor-widget-heading\" data-id=\"39a07966\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">1. \u041c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u0430\u044f \u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u0430 Tight Junctions<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5a9ee187 elementor-widget elementor-widget-text-editor\" data-id=\"5a9ee187\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-size:16px;line-height:1.75;color:#1E293B;margin:0 0 14px 0;\">Tight junctions \u2014 \u044d\u0442\u043e \u043c\u043d\u043e\u0433\u043e\u0431\u0435\u043b\u043a\u043e\u0432\u044b\u0435 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u044b, \u043e\u0431\u0440\u0430\u0437\u0443\u044e\u0449\u0438\u0435 \u0430\u043f\u0438\u043a\u0430\u043b\u044c\u043d\u0443\u044e \u0447\u0430\u0441\u0442\u044c \u043c\u0435\u0436\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u044b\u0445 \u043a\u043e\u043d\u0442\u0430\u043a\u0442\u043e\u0432. \u0421\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u043d\u043e \u043e\u043d\u0438 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043e\u0432\u0430\u043d\u044b \u0432 \u0442\u0440\u0438 \u0443\u0440\u043e\u0432\u043d\u044f:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-118f77de elementor-widget elementor-widget-heading\" data-id=\"118f77de\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">\u0423\u0440\u043e\u0432\u0435\u043d\u044c 1: \u0422\u0440\u0430\u043d\u0441\u043c\u0435\u043c\u0431\u0440\u0430\u043d\u043d\u044b\u0435 \u0431\u0435\u043b\u043a\u0438 \u2014 \u043d\u0435\u043f\u043e\u0441\u0440\u0435\u0434\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0439 \u00ab\u0437\u0430\u0442\u0432\u043e\u0440\u00bb<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-755d3954 elementor-widget elementor-widget-text-editor\" data-id=\"755d3954\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ul style=\"padding-left:22px;margin:0 0 16px 0;\"><li style=\"font-size:15px;line-height:1.7;color:#1E293B;margin-bottom:7px;\"><b>\u041e\u043a\u043a\u043b\u044e\u0434\u0438\u043d (OCLN)<\/b> \u2014 \u0447\u0435\u0442\u044b\u0440\u0435 \u0442\u0440\u0430\u043d\u0441\u043c\u0435\u043c\u0431\u0440\u0430\u043d\u043d\u044b\u0445 \u0434\u043e\u043c\u0435\u043d\u0430; \u0444\u043e\u0440\u043c\u0438\u0440\u0443\u0435\u0442 \u0444\u0438\u0437\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0431\u0430\u0440\u044c\u0435\u0440. \u0424\u043e\u0441\u0444\u043e\u0440\u0438\u043b\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435 \u043f\u043e Tyr-398\/402 (\u0437\u043e\u043d\u0443\u043b\u0438\u043d, TNF-\u03b1) \u2192 \u043f\u043e\u0442\u0435\u0440\u044f \u0444\u0443\u043d\u043a\u0446\u0438\u0438 \u2192 \u043e\u0442\u043a\u0440\u044b\u0442\u0438\u0435 \u043f\u043e\u0440\u044b. \u041a\u043b\u044e\u0447\u0435\u0432\u0430\u044f \u043c\u0438\u0448\u0435\u043d\u044c \u0442\u0435\u0440\u0430\u043f\u0438\u0438: \u0446\u0438\u043d\u043a, L-\u0433\u043b\u0443\u0442\u0430\u043c\u0438\u043d, \u0431\u0443\u0442\u0438\u0440\u0430\u0442.<\/li><li style=\"font-size:15px;line-height:1.7;color:#1E293B;margin-bottom:7px;\"><b>\u041a\u043b\u0430\u0443\u0434\u0438\u043d\u044b (CLDN 1\u201323)<\/b> \u2014 \u0433\u043b\u0430\u0432\u043d\u044b\u0435 \u00ab\u0443\u043f\u0440\u0430\u0432\u043b\u044f\u044e\u0449\u0438\u0435\u00bb \u043f\u0440\u043e\u043d\u0438\u0446\u0430\u0435\u043c\u043e\u0441\u0442\u044c\u044e: \u0440\u0430\u0437\u043d\u044b\u0435 \u043a\u043b\u0430\u0443\u0434\u0438\u043d\u044b \u0441\u043e\u0437\u0434\u0430\u044e\u0442 \u043f\u043e\u0440\u044b \u0440\u0430\u0437\u043d\u043e\u0433\u043e \u0440\u0430\u0437\u043c\u0435\u0440\u0430 \u0438 \u0438\u043e\u043d\u043d\u043e\u0439 \u0441\u0435\u043b\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438. \u041a\u043b\u0430\u0443\u0434\u0438\u043d\u044b 1, 3, 4 = \u0431\u0430\u0440\u044c\u0435\u0440\u043d\u044b\u0435; \u041a\u043b\u0430\u0443\u0434\u0438\u043d-2 = \u00ab\u043f\u0440\u043e\u0442\u0435\u043a\u0430\u044e\u0449\u0438\u0435\u00bb \u043f\u043e\u0440\u044b (\u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0439). \u0412\u0438\u0442\u0430\u043c\u0438\u043d D \u0432\u043e\u0441\u0441\u0442\u0430\u043d\u0430\u0432\u043b\u0438\u0432\u0430\u0435\u0442 \u043a\u043b\u0430\u0443\u0434\u0438\u043d-5.<\/li><li style=\"font-size:15px;line-height:1.7;color:#1E293B;margin-bottom:7px;\"><b>JAM-\u0431\u0435\u043b\u043a\u0438<\/b> (junctional adhesion molecules A, B, C) \u2014 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0443\u044e\u0442 \u043b\u0435\u0439\u043a\u043e\u0446\u0438\u0442\u0430\u0440\u043d\u0443\u044e \u0442\u0440\u0430\u043d\u0441\u043c\u0438\u0433\u0440\u0430\u0446\u0438\u044e \u0438 \u043f\u043e\u043b\u044f\u0440\u043d\u043e\u0441\u0442\u044c \u044d\u043f\u0438\u0442\u0435\u043b\u0438\u044f. JAM-A\u2193 \u043f\u0440\u0438 \u0432\u043e\u0441\u043f\u0430\u043b\u0435\u043d\u0438\u0438 \u2192 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0435 \u0431\u0430\u0440\u044c\u0435\u0440\u0430 + \u0430\u0431\u0435\u0440\u0440\u0430\u043d\u0442\u043d\u0430\u044f \u0438\u043c\u043c\u0443\u043d\u043d\u0430\u044f \u0441\u0438\u0433\u043d\u0430\u043b\u0438\u0437\u0430\u0446\u0438\u044f.<\/li><li style=\"font-size:15px;line-height:1.7;color:#1E293B;margin-bottom:7px;\"><b>\u0422\u0440\u0438\u043a\u0441\u0435\u043b\u043b\u0443\u043b\u0438\u043d (MARVELD2)<\/b> \u2014 \u0432 \u0442\u0440\u0451\u0445\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u044b\u0445 \u043a\u043e\u043d\u0442\u0430\u043a\u0442\u0430\u0445; \u0440\u0435\u0434\u043a\u0430\u044f \u043c\u0438\u0448\u0435\u043d\u044c, \u0430\u043a\u0442\u0443\u0430\u043b\u044c\u043d\u0430\u044f \u043f\u0440\u0438 \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0431\u0430\u0440\u044c\u0435\u0440\u043d\u044b\u0445 \u0434\u0435\u0444\u0435\u043a\u0442\u0430\u0445.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2371cc12 elementor-widget elementor-widget-heading\" data-id=\"2371cc12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">\u0423\u0440\u043e\u0432\u0435\u043d\u044c 2: \u041f\u0435\u0440\u0438\u0444\u0435\u0440\u0438\u0447\u0435\u0441\u043a\u0438\u0435 (\u0441\u043a\u0430\u0444\u0444\u043e\u043b\u0434\u043d\u044b\u0435) \u0431\u0435\u043b\u043a\u0438 \u2014 ZO-\u0441\u0435\u043c\u0435\u0439\u0441\u0442\u0432\u043e<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-554eccf0 elementor-widget elementor-widget-text-editor\" data-id=\"554eccf0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ul style=\"padding-left:22px;margin:0 0 16px 0;\"><li style=\"font-size:15px;line-height:1.7;color:#1E293B;margin-bottom:7px;\"><b>ZO-1 (TJP1)<\/b> \u2014 \u0433\u043b\u0430\u0432\u043d\u044b\u0439 \u0441\u043a\u0430\u0444\u0444\u043e\u043b\u0434; \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u0435\u0442 \u0442\u0440\u0430\u043d\u0441\u043c\u0435\u043c\u0431\u0440\u0430\u043d\u043d\u044b\u0435 \u0431\u0435\u043b\u043a\u0438 TJ \u0441 \u0430\u043a\u0442\u0438\u043d\u043e\u0432\u044b\u043c \u0446\u0438\u0442\u043e\u0441\u043a\u0435\u043b\u0435\u0442\u043e\u043c \u0447\u0435\u0440\u0435\u0437 PDZ-\u0434\u043e\u043c\u0435\u043d\u044b. \u042f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0434\u0430\u0442\u0447\u0438\u043a\u043e\u043c \u043c\u0435\u0445\u0430\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043d\u0430\u043f\u0440\u044f\u0436\u0435\u043d\u0438\u044f. ZO-1\u2193 = \u043a\u043b\u044e\u0447\u0435\u0432\u043e\u0439 \u043c\u0430\u0440\u043a\u0435\u0440 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u043d\u043e\u0433\u043e \u0431\u0430\u0440\u044c\u0435\u0440\u0430.<\/li><li style=\"font-size:15px;line-height:1.7;color:#1E293B;margin-bottom:7px;\"><b>ZO-2 (TJP2) \u0438 ZO-3 (TJP3)<\/b> \u2014 \u0433\u043e\u043c\u043e\u043b\u043e\u0433\u0438 ZO-1; \u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u0435 \u0440\u0435\u0437\u0435\u0440\u0432\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435, \u043d\u043e \u043f\u0440\u0438 \u043e\u0434\u043d\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u043c \u0441\u043d\u0438\u0436\u0435\u043d\u0438\u0438 \u0432\u0441\u0435\u0445 \u0442\u0440\u0451\u0445 \u2014 \u043a\u0440\u0438\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0435 \u0431\u0430\u0440\u044c\u0435\u0440\u0430.<\/li><li style=\"font-size:15px;line-height:1.7;color:#1E293B;margin-bottom:7px;\"><b>\u0410\u0444\u0430\u0434\u0438\u043d (AF-6\/MLLT4)<\/b> \u2014 \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u0435\u0442 TJ \u0441 adherens junctions; \u043d\u0430\u0440\u0443\u0448\u0430\u0435\u0442\u0441\u044f \u043f\u0440\u0438 \u043e\u043a\u0438\u0441\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u043c \u0441\u0442\u0440\u0435\u0441\u0441\u0435.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-28aed9be elementor-widget elementor-widget-heading\" data-id=\"28aed9be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">\u0423\u0440\u043e\u0432\u0435\u043d\u044c 3: \u0420\u0435\u0433\u0443\u043b\u044f\u0442\u043e\u0440\u043d\u044b\u0435 \u0441\u0438\u0433\u043d\u0430\u043b\u044c\u043d\u044b\u0435 \u0431\u0435\u043b\u043a\u0438<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-157b2a0a elementor-widget elementor-widget-text-editor\" data-id=\"157b2a0a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ul style=\"padding-left:22px;margin:0 0 16px 0;\"><li style=\"font-size:15px;line-height:1.7;color:#1E293B;margin-bottom:7px;\"><b>MLCK (myosin light chain kinase)<\/b> \u2014 \u043a\u0438\u043d\u0430\u0437\u0430, \u0444\u043e\u0441\u0444\u043e\u0440\u0438\u043b\u0438\u0440\u0443\u044e\u0449\u0430\u044f \u043b\u0451\u0433\u043a\u0438\u0435 \u0446\u0435\u043f\u0438 \u043c\u0438\u043e\u0437\u0438\u043d\u0430 \u2192 \u0441\u0436\u0430\u0442\u0438\u0435 \u0430\u043a\u0442\u0438\u043d\u043e\u0432\u043e\u0433\u043e \u043a\u043e\u043b\u044c\u0446\u0430 \u0432\u043e\u043a\u0440\u0443\u0433 \u043a\u043b\u0435\u0442\u043a\u0438 \u2192 \u043c\u0435\u0445\u0430\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u043e\u0442\u043a\u0440\u044b\u0442\u0438\u0435 TJ. \u0410\u043a\u0442\u0438\u0432\u0438\u0440\u0443\u0435\u0442\u0441\u044f TNF-\u03b1, IL-1\u03b2, \u0441\u0442\u0440\u0435\u0441\u0441\u043e\u043c, \u041d\u041f\u0412\u0421. <b>\u041a\u043b\u044e\u0447\u0435\u0432\u0430\u044f \u043c\u0438\u0448\u0435\u043d\u044c \u043a\u0432\u0435\u0440\u0446\u0435\u0442\u0438\u043d\u0430 \u0438 \u0431\u0435\u0440\u0431\u0435\u0440\u0438\u043d\u0430.<\/b><\/li><li style=\"font-size:15px;line-height:1.7;color:#1E293B;margin-bottom:7px;\"><b>PKC\u03b2 (\u043f\u0440\u043e\u0442\u0435\u0438\u043d\u043a\u0438\u043d\u0430\u0437\u0430 C\u03b2)<\/b> \u2014 \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u0443\u0435\u0442\u0441\u044f \u0437\u043e\u043d\u0443\u043b\u0438\u043d\u043e\u043c \u2192 \u0444\u043e\u0441\u0444\u043e\u0440\u0438\u043b\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435 \u043e\u043a\u043a\u043b\u044e\u0434\u0438\u043d\u0430 \u2192 TJ \u043e\u0442\u043a\u0440\u044b\u0432\u0430\u0435\u0442\u0441\u044f. \u041c\u0438\u0448\u0435\u043d\u044c: \u043f\u0440\u043e\u0431\u0438\u043e\u0442\u0438\u043a\u0438 (L. rhamnosus GG \u043c\u043e\u0434\u0443\u043b\u0438\u0440\u0443\u0435\u0442 PKC\u03b2).<\/li><li style=\"font-size:15px;line-height:1.7;color:#1E293B;margin-bottom:7px;\"><b>Rho-GTPases (RhoA, Rac1, Cdc42)<\/b> \u2014 \u0440\u0435\u0433\u0443\u043b\u044f\u0442\u043e\u0440\u044b \u0430\u043a\u0442\u0438\u043d\u043e\u0432\u043e\u0433\u043e \u0446\u0438\u0442\u043e\u0441\u043a\u0435\u043b\u0435\u0442\u0430; \u0438\u0445 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0435 \u043f\u0440\u0438 C.diff-\u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0438 \u2192 \u043a\u0430\u0442\u0430\u0441\u0442\u0440\u043e\u0444\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0440\u0430\u0437\u0440\u0443\u0448\u0435\u043d\u0438\u0435 TJ.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-30e79a6d elementor-widget elementor-widget-text-editor\" data-id=\"30e79a6d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"background:#EFF6FF;border-left:4px solid #1E40AF;border-radius:0 8px 8px 0;padding:16px 20px;margin-bottom:16px;\"><b>\u041a\u043b\u044e\u0447\u0435\u0432\u043e\u0439 \u043f\u0440\u0438\u043d\u0446\u0438\u043f \u0442\u0435\u0440\u0430\u043f\u0438\u0438:<\/b> \u043f\u043e\u0441\u043a\u043e\u043b\u044c\u043a\u0443 TJ-\u0431\u0435\u043b\u043a\u0438 \u0440\u0435\u0433\u0443\u043b\u0438\u0440\u0443\u044e\u0442\u0441\u044f \u0447\u0435\u0440\u0435\u0437 <b>\u0440\u0430\u0437\u043d\u044b\u0435 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u044b\u0435 \u043f\u0443\u0442\u0438<\/b>, \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u0430\u044f \u0441\u0442\u0440\u0430\u0442\u0435\u0433\u0438\u044f \u0432\u043e\u0441\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u0438\u044f \u0431\u0430\u0440\u044c\u0435\u0440\u0430 \u0434\u043e\u043b\u0436\u043d\u0430 \u0432\u043e\u0437\u0434\u0435\u0439\u0441\u0442\u0432\u043e\u0432\u0430\u0442\u044c \u043d\u0430 \u043d\u0435\u0441\u043a\u043e\u043b\u044c\u043a\u043e \u043c\u0438\u0448\u0435\u043d\u0435\u0439 \u043e\u0434\u043d\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e. \u00ab\u041c\u043e\u043d\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f\u00bb \u043e\u0434\u043d\u0438\u043c \u043d\u0443\u0442\u0440\u0438\u0435\u043d\u0442\u043e\u043c \u043c\u0435\u043d\u0435\u0435 \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u0430, \u0447\u0435\u043c \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0439 \u043f\u0440\u043e\u0442\u043e\u043a\u043e\u043b.<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-680fca57 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"680fca57\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e7ffc32\" data-id=\"e7ffc32\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-66e4530b elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"66e4530b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-691d7c49 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"691d7c49\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b0a5a8a\" data-id=\"b0a5a8a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-23af0761 elementor-widget elementor-widget-heading\" data-id=\"23af0761\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2. \u0424\u0443\u043d\u043a\u0446\u0438\u0438 Tight Junctions: \u0442\u0440\u0438 \u0443\u0440\u043e\u0432\u043d\u044f \u0437\u043d\u0430\u0447\u0438\u043c\u043e\u0441\u0442\u0438<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-733ad547 elementor-widget elementor-widget-html\" data-id=\"733ad547\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<div style=\"overflow-x:auto;margin-bottom:20px;\"><table style=\"width:100%;border-collapse:collapse;font-family:Arial,sans-serif;\"><thead><tr><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u0424\u0443\u043d\u043a\u0446\u0438\u044f<\/th><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u041c\u0435\u0445\u0430\u043d\u0438\u0437\u043c<\/th><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0437\u043d\u0430\u0447\u0438\u043c\u043e\u0441\u0442\u044c \u043f\u043e\u0442\u0435\u0440\u0438<\/th><\/tr><\/thead><tbody><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u0411\u0430\u0440\u044c\u0435\u0440\u043d\u0430\u044f (\u0440\u0430\u0437\u043c\u0435\u0440\u043e\u0441\u0441\u0435\u043b\u0435\u043a\u0442\u0438\u0432\u043d\u044b\u0439 \u0444\u0438\u043b\u044c\u0442\u0440)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u041e\u0433\u0440\u0430\u043d\u0438\u0447\u0438\u0432\u0430\u044e\u0442 \u043f\u0430\u0440\u0430\u0446\u0435\u043b\u043b\u044e\u043b\u044f\u0440\u043d\u044b\u0439 \u0442\u0440\u0430\u043d\u0437\u0438\u0442 \u043f\u043e \u0440\u0430\u0437\u043c\u0435\u0440\u0443 \u0438 \u0437\u0430\u0440\u044f\u0434\u0443 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044b<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u041b\u041f\u0421, \u043d\u0435\u043f\u0435\u0440\u0435\u0432\u0430\u0440\u0435\u043d\u043d\u044b\u0435 \u0430\u043d\u0442\u0438\u0433\u0435\u043d\u044b, \u0442\u043e\u043a\u0441\u0438\u043d\u044b \u2192 \u043a\u0440\u043e\u0432\u043e\u0442\u043e\u043a \u2192 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0432\u043e\u0441\u043f\u0430\u043b\u0435\u043d\u0438\u0435, \u0430\u0443\u0442\u043e\u0438\u043c\u043c\u0443\u043d\u0438\u0442\u0435\u0442<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u041f\u043e\u043b\u044f\u0440\u043d\u043e\u0441\u0442\u044c \u044d\u043f\u0438\u0442\u0435\u043b\u0438\u044f (\u0430\u043f\u0438\u043a\u0430\u043b\u044c\u043d\u043e-\u0431\u0430\u0437\u0430\u043b\u044c\u043d\u0430\u044f)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u0420\u0430\u0437\u0434\u0435\u043b\u044f\u044e\u0442 \u0430\u043f\u0438\u043a\u0430\u043b\u044c\u043d\u0443\u044e (\u043f\u0440\u043e\u0441\u0432\u0435\u0442\u043d\u0443\u044e) \u0438 \u0431\u0430\u0437\u043e\u043b\u0430\u0442\u0435\u0440\u0430\u043b\u044c\u043d\u0443\u044e (\u0438\u043d\u0442\u0435\u0440\u0441\u0442\u0438\u0446\u0438\u0430\u043b\u044c\u043d\u0443\u044e) \u043c\u0435\u043c\u0431\u0440\u0430\u043d\u044b<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u041d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0435 \u043f\u043e\u043b\u044f\u0440\u0438\u0437\u0430\u0446\u0438\u0438 \u2192 \u0430\u0431\u0435\u0440\u0440\u0430\u043d\u0442\u043d\u0430\u044f \u0441\u0435\u043a\u0440\u0435\u0446\u0438\u044f \u2192 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0435 pH, \u043f\u0438\u0449\u0435\u0432\u0430\u0440\u0435\u043d\u0438\u044f, \u0438\u043c\u043c\u0443\u043d\u043d\u043e\u0433\u043e \u043d\u0430\u0434\u0437\u043e\u0440\u0430<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u0418\u043c\u043c\u0443\u043d\u043d\u0430\u044f \u0441\u0438\u0433\u043d\u0430\u043b\u0438\u0437\u0430\u0446\u0438\u044f<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">ZO-1 \u0442\u0440\u0430\u043d\u0441\u043b\u043e\u0446\u0438\u0440\u0443\u0435\u0442\u0441\u044f \u0432 \u044f\u0434\u0440\u043e \u043f\u0440\u0438 \u0441\u0442\u0440\u0435\u0441\u0441\u0435 \u2192 \u0440\u0435\u0433\u0443\u043b\u044f\u0446\u0438\u044f \u0433\u0435\u043d\u043e\u0432 \u0432\u043e\u0441\u043f\u0430\u043b\u0435\u043d\u0438\u044f<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">ZO-1-\u0434\u0435\u0444\u0438\u0446\u0438\u0442 \u2192 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0435 \u044f\u0434\u0435\u0440\u043d\u043e\u0433\u043e \u0440\u0435\u0433\u0443\u043b\u044f\u0442\u043e\u0440\u043d\u043e\u0433\u043e \u043f\u0443\u0442\u0438 \u2192 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0438\u043c\u043c\u0443\u043d\u043d\u0430\u044f \u0430\u043a\u0442\u0438\u0432\u0430\u0446\u0438\u044f<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u041c\u0435\u0445\u0430\u043d\u043e\u0441\u0435\u043d\u0441\u0438\u043d\u0433<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">MLCK \u0440\u0435\u0430\u0433\u0438\u0440\u0443\u0435\u0442 \u043d\u0430 \u043c\u0435\u0445\u0430\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u043d\u0430\u043f\u0440\u044f\u0436\u0435\u043d\u0438\u0435 \u0441\u0442\u0435\u043d\u043a\u0438 \u043a\u0438\u0448\u043a\u0438<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u041f\u0440\u0438 \u043a\u0438\u0448\u0435\u0447\u043d\u043e\u0439 \u0433\u0438\u043f\u0435\u0440\u043f\u043e\u0434\u0432\u0438\u0436\u043d\u043e\u0441\u0442\u0438 \u0438\u043b\u0438 \u043e\u0431\u0441\u0442\u0440\u0443\u043a\u0446\u0438\u0438 \u2014 \u0442\u0440\u0430\u043d\u0437\u0438\u0442\u043e\u0440\u043d\u0430\u044f \u0433\u0438\u043f\u0435\u0440\u043f\u0440\u043e\u043d\u0438\u0446\u0430\u0435\u043c\u043e\u0441\u0442\u044c \u0447\u0435\u0440\u0435\u0437 MLCK<\/td><\/tr><\/tbody><\/table><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5ca52ac elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5ca52ac\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3f02a27f\" data-id=\"3f02a27f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c01d32f elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"c01d32f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-48590566 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"48590566\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-37df3e1c\" data-id=\"37df3e1c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6adf7d20 elementor-widget elementor-widget-heading\" data-id=\"6adf7d20\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">3. \u0427\u0442\u043e \u0440\u0430\u0437\u0440\u0443\u0448\u0430\u0435\u0442 Tight Junctions \u2014 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u044b\u0435 \u043c\u0438\u0448\u0435\u043d\u0438 \u0438 \u0442\u0440\u0438\u0433\u0433\u0435\u0440\u044b<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1940efda elementor-widget elementor-widget-html\" data-id=\"1940efda\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<div style=\"overflow-x:auto;margin-bottom:20px;\"><table style=\"width:100%;border-collapse:collapse;font-family:Arial,sans-serif;\"><thead><tr><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u0422\u0440\u0438\u0433\u0433\u0435\u0440<\/th><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u0411\u0435\u043b\u043e\u043a-\u043c\u0438\u0448\u0435\u043d\u044c<\/th><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u041c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u044b\u0439 \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c<\/th><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u0423\u0440\u043e\u0432\u0435\u043d\u044c \u0434\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u0438<\/th><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0435<\/th><\/tr><\/thead><tbody><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u0417\u043e\u043d\u0443\u043b\u0438\u043d (\u0433\u043b\u044e\u0442\u0435\u043d, \u041b\u041f\u0421)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u041e\u043a\u043a\u043b\u044e\u0434\u0438\u043d, ZO-1<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">EGF-R \u2192 PKC\u03b2 \u2192 \u0444\u043e\u0441\u0444\u043e-Tyr \u043e\u043a\u043a\u043b\u044e\u0434\u0438\u043d\u0430 \u2192 \u0434\u0435\u0437\u043e\u0440\u0433\u0430\u043d\u0438\u0437\u0430\u0446\u0438\u044f ZO-1<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">High (Fasano 2000\u20132019; Drago 2006)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u0426\u0435\u043b\u0438\u0430\u043a\u0438\u044f, \u041d\u0426\u0413\u0427, \u0434\u0438\u0441\u0431\u0438\u043e\u0437; \u043e\u0431\u0440\u0430\u0442\u0438\u043c<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">TNF-\u03b1<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u041e\u043a\u043a\u043b\u044e\u0434\u0438\u043d, ZO-1, \u043a\u043b\u0430\u0443\u0434\u0438\u043d-5<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u2191MLCK \u2192 \u0441\u0436\u0430\u0442\u0438\u0435 \u0430\u043a\u0442\u0438\u043d\u0430; \u2191\u044d\u043d\u0434\u043e\u0446\u0438\u0442\u043e\u0437 \u043e\u043a\u043a\u043b\u044e\u0434\u0438\u043d\u0430; \u2191\u0443\u0431\u0438\u043a\u0432\u0438\u0442\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435 ZO-1<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">High \u2014 \u0412\u0417\u041a-\u0434\u0430\u043d\u043d\u044b\u0435 + RCT<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u0412\u0417\u041a, \u0420\u0410, \u0441\u0435\u043f\u0441\u0438\u0441; \u043a\u043b\u044e\u0447\u0435\u0432\u0430\u044f \u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442. \u043c\u0438\u0448\u0435\u043d\u044c<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">IFN-\u03b3<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">ZO-1, \u043a\u043b\u0430\u0443\u0434\u0438\u043d-1<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u2193\u043c\u0420\u041d\u041a ZO-1; \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0435 \u043b\u0430\u0442\u0435\u0440\u0430\u043b\u044c\u043d\u043e\u0439 \u043b\u043e\u043a\u0430\u043b\u0438\u0437\u0430\u0446\u0438\u0438 \u043a\u043b\u0430\u0443\u0434\u0438\u043d\u0430-1 \u0432 TJ<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">High \u2014 \u0446\u0435\u043b\u0438\u0430\u043a\u0438\u0439\u043d\u044b\u0435 \u0431\u0438\u043e\u043f\u0441\u0438\u0438<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u0426\u0435\u043b\u0438\u0430\u043a\u0438\u044f, \u0412\u0417\u041a; \u0443\u0441\u0438\u043b\u0438\u0432\u0430\u0435\u0442 \u044d\u0444\u0444\u0435\u043a\u0442 TNF-\u03b1<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">IL-13<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u041a\u043b\u0430\u0443\u0434\u0438\u043d-2 (\u2191\u043f\u0430\u0442\u043e\u043b.)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u041f\u0430\u0440\u0430\u0434\u043e\u043a\u0441: \u2191\u0442\u0440\u0430\u043d\u0441\u043a\u0440\u0438\u043f\u0446\u0438\u044e \u043a\u043b\u0430\u0443\u0434\u0438\u043d\u0430-2 \u2192 \u00ab\u043f\u0440\u043e\u0442\u0435\u043a\u0430\u044e\u0449\u0438\u0435\u00bb \u043f\u043e\u0440\u044b \u0434\u043b\u044f Na\u207a \u0438 \u0432\u043e\u0434\u044b<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">High \u2014 RCT \u043f\u0440\u0438 \u0412\u0417\u041a<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u0410\u0442\u043e\u043f\u0438\u044f, \u0412\u0417\u041a; \u043e\u0431\u044a\u044f\u0441\u043d\u044f\u0435\u0442 \u0434\u0438\u0430\u0440\u0435\u044e \u043f\u0440\u0438 \u2191IL-13<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u041b\u041f\u0421 (\u0433\u0440\u0430\u043c\u043e\u0442\u0440\u0438\u0446. \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0438)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u041c\u043d\u043e\u0436\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0435 TJ-\u0431\u0435\u043b\u043a\u0438<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">TLR4-NF-\u03baB \u2192 \u0446\u0438\u0442\u043e\u043a\u0438\u043d\u044b \u2192 \u0432\u0442\u043e\u0440\u0438\u0447\u043d\u043e\u0435 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0435 TJ<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">High \u2014 animal + in vitro + cohort<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u0414\u0438\u0441\u0431\u0438\u043e\u0437, \u043e\u0436\u0438\u0440\u0435\u043d\u0438\u0435, \u044d\u043d\u0434\u043e\u0442\u043e\u043a\u0441\u0435\u043c\u0438\u044f<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u0410\u043b\u043a\u043e\u0433\u043e\u043b\u044c \/ \u0430\u0446\u0435\u0442\u0430\u043b\u044c\u0434\u0435\u0433\u0438\u0434<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u041e\u043a\u043a\u043b\u044e\u0434\u0438\u043d, ZO-1<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u041f\u0440\u044f\u043c\u043e\u0435 \u043a\u043e\u0432\u0430\u043b\u0435\u043d\u0442\u043d\u043e\u0435 \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u043d\u0438\u0435 \u0430\u0446\u0435\u0442\u0430\u043b\u044c\u0434\u0435\u0433\u0438\u0434\u0430 \u0441 \u0431\u0435\u043b\u043a\u0430\u043c\u0438 TJ \u2192 \u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u043d\u043e\u0435 \u043f\u043e\u0432\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u0435<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">High (Purohit 2008; Leclercq 2012)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u0425\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0437\u043b\u043e\u0443\u043f\u043e\u0442\u0440\u0435\u0431\u043b\u0435\u043d\u0438\u0435; >14 \u0435\u0434.\/\u043d\u0435\u0434. \u2191LBP 28%<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">MLCK-\u0430\u043a\u0442\u0438\u0432\u0430\u0446\u0438\u044f (\u0441\u0442\u0440\u0435\u0441\u0441, TNF-\u03b1)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u041b\u0451\u0433\u043a\u0438\u0435 \u0446\u0435\u043f\u0438 \u043c\u0438\u043e\u0437\u0438\u043d\u0430 \u2192 \u0430\u043a\u0442\u0438\u043d\u043e\u0432\u043e\u0435 \u043a\u043e\u043b\u044c\u0446\u043e<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u2191\u0444\u043e\u0441\u0444\u043e-MLC20 \u2192 \u0441\u043e\u043a\u0440\u0430\u0449\u0435\u043d\u0438\u0435 \u0430\u043a\u0442\u0438\u043d\u0430 \u2192 \u043c\u0435\u0445\u0430\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0440\u0430\u0441\u0448\u0438\u0440\u0435\u043d\u0438\u0435 \u043f\u0430\u0440. \u043f\u043e\u0440\u044b<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">High \u2014 \u0436\u0438\u0432\u043e\u0442\u043d\u044b\u0435 + RCT<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u0411\u044b\u0441\u0442\u0440\u0430\u044f (\u043c\u0438\u043d\u0443\u0442\u044b) \u0438 \u043e\u0431\u0440\u0430\u0442\u0438\u043c\u0430\u044f \u041f\u041a\u041f; \u043c\u0438\u0448\u0435\u043d\u044c \u043a\u0432\u0435\u0440\u0446\u0435\u0442\u0438\u043d\u0430, \u0431\u0435\u0440\u0431\u0435\u0440\u0438\u043d\u0430<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">C. difficile \u0442\u043e\u043a\u0441\u0438\u043d B<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u041a\u043b\u0430\u0443\u0434\u0438\u043d-5, Rho-GTPases<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u0418\u043d\u0430\u043a\u0442\u0438\u0432\u0430\u0446\u0438\u044f Rho \u2192 \u0434\u0435\u043f\u043e\u043b\u0438\u043c\u0435\u0440\u0438\u0437\u0430\u0446\u0438\u044f \u0430\u043a\u0442\u0438\u043d\u0430 \u2192 \u043a\u0430\u0442\u0430\u0441\u0442\u0440\u043e\u0444\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0440\u0430\u0437\u0440\u0443\u0448\u0435\u043d\u0438\u0435 TJ<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">High \u2014 \u043c\u0435\u0445\u0430\u043d\u0438\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0438<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">C.diff-\u043a\u043e\u043b\u0438\u0442; \u043e\u0431\u044a\u044f\u0441\u043d\u044f\u0435\u0442 \u0432\u044b\u0440\u0430\u0436\u0435\u043d\u043d\u0443\u044e \u0434\u0438\u0430\u0440\u0435\u044e<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u041d\u041f\u0412\u0421 (\u0438\u0431\u0443\u043f\u0440\u043e\u0444\u0435\u043d, \u0438\u043d\u0434\u043e\u043c\u0435\u0442\u0430\u0446\u0438\u043d)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u041f\u0440\u043e\u0441\u0442\u0430\u0433\u043b\u0430\u043d\u0434\u0438\u043d \u04152 (\u043d\u0435\u043f\u0440\u044f\u043c\u043e\u0439)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u0426\u041e\u0413-\u0438\u043d\u0433\u0438\u0431\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435 \u2192 \u2193PGE2 \u2192 \u043f\u043e\u0442\u0435\u0440\u044f \u0446\u0410\u041c\u0424-\u0437\u0430\u0432\u0438\u0441\u0438\u043c\u043e\u0439 \u0437\u0430\u0449\u0438\u0442\u044b TJ<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">High \u2014 RCT + cohort<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u0425\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u0435; \u043e\u0431\u0440\u0430\u0442\u0438\u043c\u043e \u043f\u0440\u0438 \u043e\u0442\u043c\u0435\u043d\u0435<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u0413\u0438\u043f\u043e\u043a\u0441\u0438\u044f (\u0438\u043d\u0442\u0435\u043d\u0441\u0438\u0432\u043d\u0430\u044f \u043d\u0430\u0433\u0440\u0443\u0437\u043a\u0430, \u0441\u0435\u043f\u0441\u0438\u0441)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u041c\u043d\u043e\u0436\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0435 TJ-\u0431\u0435\u043b\u043a\u0438<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u2193\u0410\u0422\u0424 \u2192 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0435 \u0430\u043a\u0442\u0438\u043d\u043e\u0432\u043e\u0433\u043e \u0446\u0438\u0442\u043e\u0441\u043a\u0435\u043b\u0435\u0442\u0430; \u2191ROS \u2192 \u043e\u043a\u0438\u0441\u043b\u0435\u043d\u0438\u0435 ZO-1<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">High \u2014 animal; Moderate \u2014 human<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u00abExercise-induced gut permeability\u00bb; \u0441\u0435\u043f\u0441\u0438\u0441-\u0430\u0441\u0441\u043e\u0446. \u041f\u041a\u041f<\/td><\/tr><\/tbody><\/table><\/div>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-49b7735f elementor-widget elementor-widget-text-editor\" data-id=\"49b7735f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"background: #F0F9FF; border: 1px solid #BAE6FD; border-radius: 8px; padding: 12px 18px; margin-bottom: 10px;\"><p><span style=\"color: #0284c7; font-size: 15px; font-weight: 600;\">\u2192 <\/span><a style=\"color: #0284c7; font-size: 15px; font-weight: 600; text-decoration: none;\" href=\"https:\/\/novolakrb1.ru\/statii\/zonulin-analiz-normy\/\">\u0417\u043e\u043d\u0443\u043b\u0438\u043d-\u0437\u0430\u0432\u0438\u0441\u0438\u043c\u044b\u0439 \u043f\u0443\u0442\u044c \u043f\u043e\u0434\u0440\u043e\u0431\u043d\u043e: \u0430\u043d\u0430\u043b\u0438\u0437, \u043d\u043e\u0440\u043c\u044b, \u0441\u043d\u0438\u0436\u0435\u043d\u0438\u0435<\/a><\/p><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6b99d995 elementor-widget elementor-widget-text-editor\" data-id=\"6b99d995\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"background: #F0F9FF; border: 1px solid #BAE6FD; border-radius: 8px; padding: 12px 18px; margin-bottom: 10px;\"><p><span style=\"color: #0284c7; font-size: 15px; font-weight: 600;\">\u2192 <\/span><a style=\"color: #0284c7; font-size: 15px; font-weight: 600; text-decoration: none;\" href=\"https:\/\/novolakrb1.ru\/statii\/mikrobiom-dyravyy-kishechnik\/\">\u0414\u0438\u0441\u0431\u0438\u043e\u0437 \u043a\u0430\u043a \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u044b\u0439 \u0438\u0441\u0442\u043e\u0447\u043d\u0438\u043a LPS \u0438 TJ-\u043f\u043e\u0432\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u044f<\/a><\/p><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1a64f85c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1a64f85c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2b1fa16b\" data-id=\"2b1fa16b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-190cab07 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"190cab07\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-691bf31e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"691bf31e\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3363eb86\" data-id=\"3363eb86\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-10d0ca90 elementor-widget elementor-widget-heading\" data-id=\"10d0ca90\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">4. MLCK-\u0437\u0430\u0432\u0438\u0441\u0438\u043c\u044b\u0439 \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c \u2014 \u043a\u043b\u044e\u0447\u0435\u0432\u043e\u0439 \u043f\u0443\u0442\u044c \u043e\u0442\u043a\u0440\u044b\u0442\u0438\u044f TJ<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bb0b59b elementor-widget elementor-widget-text-editor\" data-id=\"bb0b59b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-size:16px;line-height:1.75;color:#1E293B;margin:0 0 14px 0;\"><b>MLCK (myosin light chain kinase, \u043a\u0438\u043d\u0430\u0437\u0430 \u043b\u0451\u0433\u043a\u043e\u0439 \u0446\u0435\u043f\u0438 \u043c\u0438\u043e\u0437\u0438\u043d\u0430)<\/b> \u2014 \u0446\u0435\u043d\u0442\u0440\u0430\u043b\u044c\u043d\u044b\u0439 \u0438\u0441\u043f\u043e\u043b\u043d\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0439 \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c \u043e\u0442\u043a\u0440\u044b\u0442\u0438\u044f TJ \u043f\u0440\u0438 \u0432\u043e\u0441\u043f\u0430\u043b\u0435\u043d\u0438\u0438 \u0438 \u0441\u0442\u0440\u0435\u0441\u0441\u0435. \u042d\u0442\u043e \u043d\u0435 \u043f\u0440\u043e\u0441\u0442\u043e \u0431\u0438\u043e\u0445\u0438\u043c\u0438\u044f: MLCK \u043e\u0431\u044a\u044f\u0441\u043d\u044f\u0435\u0442, \u043f\u043e\u0447\u0435\u043c\u0443 \u0441\u0442\u0440\u0435\u0441\u0441, \u0432\u043e\u0441\u043f\u0430\u043b\u0435\u043d\u0438\u0435 \u0438 TNF-\u03b1 \u0442\u0430\u043a \u0431\u044b\u0441\u0442\u0440\u043e \u043d\u0430\u0440\u0443\u0448\u0430\u044e\u0442 \u0431\u0430\u0440\u044c\u0435\u0440 \u0438 \u043f\u043e\u0447\u0435\u043c\u0443 \u043a\u0432\u0435\u0440\u0446\u0435\u0442\u0438\u043d \u0438 \u0431\u0435\u0440\u0431\u0435\u0440\u0438\u043d \u043f\u043e\u043a\u0430\u0437\u044b\u0432\u0430\u044e\u0442 \u044d\u0444\u0444\u0435\u043a\u0442.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-16801d4f elementor-widget elementor-widget-text-editor\" data-id=\"16801d4f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ul style=\"padding-left:22px;margin:0 0 16px 0;\"><li style=\"font-size:15px;line-height:1.7;color:#1E293B;margin-bottom:7px;\"><b>TNF-\u03b1 \u0438\u043b\u0438 IL-1\u03b2 \u2192 TNFR1 \u043d\u0430 \u044d\u043f\u0438\u0442\u0435\u043b\u0438\u043e\u0446\u0438\u0442\u0435<\/b> \u2192 \u0430\u043a\u0442\u0438\u0432\u0430\u0446\u0438\u044f NF-\u03baB \u2192 \u2191\u0442\u0440\u0430\u043d\u0441\u043a\u0440\u0438\u043f\u0446\u0438\u044f \u0433\u0435\u043d\u0430 MLCK \u2192 \u0441\u0438\u043d\u0442\u0435\u0437 MLCK\u2191<\/li><li style=\"font-size:15px;line-height:1.7;color:#1E293B;margin-bottom:7px;\"><b>MLCK + Ca\u00b2\u207a\/\u043a\u0430\u043b\u044c\u043c\u043e\u0434\u0443\u043b\u0438\u043d \u2192 \u0444\u043e\u0441\u0444\u043e\u0440\u0438\u043b\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435 MLC20<\/b> (\u043b\u0451\u0433\u043a\u043e\u0439 \u0446\u0435\u043f\u0438 \u043c\u0438\u043e\u0437\u0438\u043d\u0430 \u043f\u043e Ser-19)<\/li><li style=\"font-size:15px;line-height:1.7;color:#1E293B;margin-bottom:7px;\"><b>\u0424\u043e\u0441\u0444\u043e-MLC20 + \u043d\u0435\u0444\u043e\u0441\u0444\u043e\u0440\u0438\u043b\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0439 \u043c\u0438\u043e\u0437\u0438\u043d II<\/b> \u2192 \u0430\u043a\u0442\u0438\u043d-\u043c\u0438\u043e\u0437\u0438\u043d\u043e\u0432\u043e\u0435 \u0441\u043e\u043a\u0440\u0430\u0449\u0435\u043d\u0438\u0435 \u043f\u0435\u0440\u0438\u0446\u0435\u043b\u043b\u044e\u043b\u044f\u0440\u043d\u043e\u0433\u043e F-\u0430\u043a\u0442\u0438\u043d\u043e\u0432\u043e\u0433\u043e \u043a\u043e\u043b\u044c\u0446\u0430<\/li><li style=\"font-size:15px;line-height:1.7;color:#1E293B;margin-bottom:7px;\"><b>\u041c\u0435\u0445\u0430\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u043d\u0430\u0442\u044f\u0436\u0435\u043d\u0438\u0435 \u0432\u043e\u043a\u0440\u0443\u0433 \u043a\u043b\u0435\u0442\u043a\u0438<\/b> \u2192 \u0433\u0435\u043e\u043c\u0435\u0442\u0440\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0440\u0430\u0441\u0448\u0438\u0440\u0435\u043d\u0438\u0435 \u043f\u0430\u0440\u0430\u0446\u0435\u043b\u043b\u044e\u043b\u044f\u0440\u043d\u043e\u0439 \u043f\u043e\u0440\u044b \u2192 \u2191\u0442\u0440\u0430\u043d\u0437\u0438\u0442 4 \u043a\u0414\u0430-\u0434\u0435\u043a\u0441\u0442\u0440\u0430\u043d\u0430 (\u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0439 \u043c\u0430\u0440\u043a\u0435\u0440).<\/li><li style=\"font-size:15px;line-height:1.7;color:#1E293B;margin-bottom:7px;\"><b>\u041f\u0430\u0440\u0430\u043b\u043b\u0435\u043b\u044c\u043d\u043e:<\/b> \u0430\u043a\u0442\u0438\u0432\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0439 MLCK \u0444\u043e\u0441\u0444\u043e\u0440\u0438\u043b\u0438\u0440\u0443\u0435\u0442 ZO-1 \u2192 \u0434\u0435\u0441\u0442\u0430\u0431\u0438\u043b\u0438\u0437\u0430\u0446\u0438\u044f \u0441\u043a\u0430\u0444\u0444\u043e\u043b\u0434\u0430 \u2192 \u0434\u043e\u043f\u043e\u043b\u043d\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0435 \u043e\u0442\u043a\u0440\u044b\u0442\u0438\u0435 TJ<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5de83349 elementor-widget elementor-widget-text-editor\" data-id=\"5de83349\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"background:#EFF6FF;border-left:4px solid #1E40AF;border-radius:0 8px 8px 0;padding:16px 20px;margin-bottom:16px;\"><b>\u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0435 MLCK-\u043f\u0443\u0442\u0438:<\/b><br>\n      \u2022 <b>\u0421\u043a\u043e\u0440\u043e\u0441\u0442\u044c:<\/b> MLCK-\u0437\u0430\u0432\u0438\u0441\u0438\u043c\u043e\u0435 \u043e\u0442\u043a\u0440\u044b\u0442\u0438\u0435 TJ \u043f\u0440\u043e\u0438\u0441\u0445\u043e\u0434\u0438\u0442 \u0437\u0430 30\u201360 \u043c\u0438\u043d\u0443\u0442 \u2014 \u0432 \u043e\u0442\u043b\u0438\u0447\u0438\u0435 \u043e\u0442 \u0442\u0440\u0430\u043d\u0441\u043a\u0440\u0438\u043f\u0446\u0438\u043e\u043d\u043d\u043e\u0433\u043e (\u0437\u043e\u043d\u0443\u043b\u0438\u043d, \u0446\u0438\u0442\u043e\u043a\u0438\u043d\u044b) \u2014 \u0447\u0430\u0441\u044b\/\u0434\u043d\u0438<br>\n      \u2022 <b>\u041e\u0431\u0440\u0430\u0442\u0438\u043c\u043e\u0441\u0442\u044c:<\/b> \u043f\u0440\u0438 \u0443\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u0438\u0438 MLCK-\u0430\u043a\u0442\u0438\u0432\u0430\u0442\u043e\u0440\u0430 (\u0441\u0442\u0440\u0435\u0441\u0441, TNF-\u03b1) \u2192 TJ \u0437\u0430\u043a\u0440\u044b\u0432\u0430\u044e\u0442\u0441\u044f \u0437\u0430 1\u20134 \u0447<br>\n      \u2022 <b>\u0422\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u043c\u0438\u0448\u0435\u043d\u044c:<\/b> MLCK-\u0438\u043d\u0433\u0438\u0431\u0438\u0442\u043e\u0440\u044b (\u043a\u0432\u0435\u0440\u0446\u0435\u0442\u0438\u043d, \u0431\u0435\u0440\u0431\u0435\u0440\u0438\u043d, ML-7 \u0432 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f\u0445) \u2192 \u0431\u043b\u043e\u043a\u0438\u0440\u0443\u044e\u0442 \u044d\u0442\u043e\u0442 \u043f\u0443\u0442\u044c; \u043f\u0440\u043e\u0431\u0438\u043e\u0442\u0438\u043a L.rhamnosus GG \u2192 \u0441\u043d\u0438\u0436\u0430\u0435\u0442 \u044d\u043a\u0441\u043f\u0440\u0435\u0441\u0441\u0438\u044e MLCK \u0447\u0435\u0440\u0435\u0437 PKC-\u0437\u0430\u0432\u0438\u0441\u0438\u043c\u044b\u0439 \u043f\u0443\u0442\u044c<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-376b2637 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"376b2637\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-32a37d16\" data-id=\"32a37d16\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6579ad24 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"6579ad24\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-48e5ad87 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"48e5ad87\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4fde41ab\" data-id=\"4fde41ab\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-35d3688c elementor-widget elementor-widget-heading\" data-id=\"35d3688c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">5. \u041d\u0443\u0442\u0440\u0438\u0446\u0435\u0432\u0442\u0438\u043a\u0438 \u0434\u043b\u044f \u0432\u043e\u0441\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u0438\u044f Tight Junctions \u2014 \u043f\u043e\u043b\u043d\u0430\u044f \u0442\u0430\u0431\u043b\u0438\u0446\u0430<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-460b04dd elementor-widget elementor-widget-text-editor\" data-id=\"460b04dd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"background:#EFF6FF;border-left:4px solid #1E40AF;border-radius:0 8px 8px 0;padding:16px 20px;margin-bottom:16px;\"><b>\u041f\u0440\u0438\u043d\u0446\u0438\u043f\u0438\u0430\u043b\u044c\u043d\u044b\u0439 \u043c\u043e\u043c\u0435\u043d\u0442:<\/b> \u043d\u0443\u0442\u0440\u0438\u0435\u043d\u0442\u044b \u0434\u0435\u0439\u0441\u0442\u0432\u0443\u044e\u0442 \u043d\u0430 <b>\u0440\u0430\u0437\u043d\u044b\u0435 \u0431\u0435\u043b\u043a\u0438 \u0438 \u043f\u0443\u0442\u0438 TJ<\/b>. \u041a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0439 \u043f\u0440\u043e\u0442\u043e\u043a\u043e\u043b (\u0431\u0443\u0442\u0438\u0440\u0430\u0442 + \u0432\u0438\u0442\u0430\u043c\u0438\u043d D + \u0446\u0438\u043d\u043a + \u043f\u0440\u043e\u0431\u0438\u043e\u0442\u0438\u043a) \u0431\u043e\u043b\u0435\u0435 \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u0435\u043d, \u0447\u0435\u043c \u043c\u043e\u043d\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f. \u0423\u0440\u043e\u0432\u043d\u0438 \u0434\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u0438 \u043f\u0440\u0438\u0432\u0435\u0434\u0435\u043d\u044b \u0434\u043b\u044f \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u0438\u043c\u0435\u043d\u043d\u043e \u043f\u0440\u0438 leaky gut \/ intestinal permeability.<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-22e32ad5 elementor-widget elementor-widget-html\" data-id=\"22e32ad5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<div style=\"overflow-x:auto;margin-bottom:20px;\"><table style=\"width:100%;border-collapse:collapse;font-family:Arial,sans-serif;\"><thead><tr><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u041d\u0443\u0442\u0440\u0438\u0435\u043d\u0442<\/th><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u041c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u0430\u044f \u043c\u0438\u0448\u0435\u043d\u044c TJ<\/th><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u041c\u0435\u0445\u0430\u043d\u0438\u0437\u043c<\/th><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u0414\u043e\u0437\u0438\u0440\u043e\u0432\u043a\u0430<\/th><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u0423\u0440\u043e\u0432\u0435\u043d\u044c \u0434\u043e\u043a\u0430\u0437\u0430\u0442.<\/th><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u041e\u0433\u0440\u0430\u043d\u0438\u0447\u0435\u043d\u0438\u044f\/\u043f\u0440\u0438\u043c\u0435\u0447\u0430\u043d\u0438\u044f<\/th><\/tr><\/thead><tbody><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">L-\u0433\u043b\u0443\u0442\u0430\u043c\u0438\u043d<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">ZO-1, \u043a\u043b\u0430\u0443\u0434\u0438\u043d-5; \u0441\u0438\u043d\u0442\u0435\u0437 \u0433\u043b\u0443\u0442\u0430\u0442\u0438\u043e\u043d\u0430<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u041f\u0438\u0442\u0430\u043d\u0438\u0435 \u044d\u043d\u0442\u0435\u0440\u043e\u0446\u0438\u0442\u043e\u0432 (\u043e\u0441\u043d. \u044d\u043d\u0435\u0440\u0433\u043e\u0441\u0443\u0431\u0441\u0442\u0440\u0430\u0442) \u2192 \u2191\u0431\u0435\u043b\u043a\u043e\u0432\u044b\u0439 \u0441\u0438\u043d\u0442\u0435\u0437 TJ; \u2191GSH \u2192 \u0430\u043d\u0442\u0438\u043e\u043a\u0441\u0438\u0434\u0430\u043d\u0442\u043d\u0430\u044f \u0437\u0430\u0449\u0438\u0442\u0430<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">5\u201310 \u0433\/\u0441\u0443\u0442 (2\u20133 \u043f\u0440\u0438\u0451\u043c\u0430 \u043d\u0430\u0442\u043e\u0449\u0430\u043a)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">Moderate \u2014 RCT \u043f\u0440\u0438 \u043a\u0440\u0438\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0441\u043e\u0441\u0442\u043e\u044f\u043d\u0438\u044f\u0445 \u0438 \u0421\u0420\u041a<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u041e\u0441\u0442\u043e\u0440\u043e\u0436\u043d\u043e \u043f\u0440\u0438 \u043e\u043d\u043a\u043e\u043b\u043e\u0433\u0438\u0438 (\u0441\u043f\u043e\u0440\u043d\u043e); \u043f\u0440\u0438 \u0421\u0418\u0411\u041e \u043c\u043e\u0436\u0435\u0442 \u0443\u0441\u0438\u043b\u0438\u0442\u044c \u0433\u0430\u0437\u043e\u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u0435<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u0411\u0443\u0442\u0438\u0440\u0430\u0442 \u043d\u0430\u0442\u0440\u0438\u044f (\u043c\u0430\u0441\u043b\u044f\u043d\u0430\u044f \u043a\u0438\u0441\u043b\u043e\u0442\u0430)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">ZO-1, \u043a\u043b\u0430\u0443\u0434\u0438\u043d-1 (\u0447\u0435\u0440\u0435\u0437 HDAC); PPAR\u03b3<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">HDAC-\u0438\u043d\u0433\u0438\u0431\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435 \u2192 \u0433\u0438\u043f\u0435\u0440\u0430\u0446\u0435\u0442\u0438\u043b\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435 \u0433\u0438\u0441\u0442\u043e\u043d\u043e\u0432 \u2192 \u2191TJ-\u0433\u0435\u043d\u044b; \u2191GPR41\/43 \u2192 \u0431\u0430\u0440\u044c\u0435\u0440\u043d\u044b\u0439 \u0441\u0438\u0433\u043d\u0430\u043b<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">300\u2013600 \u043c\u0433\/\u0441\u0443\u0442 \u043a\u0438\u0448\u0435\u0447\u043d\u043e\u0440\u0430\u0441\u0442\u0432\u043e\u0440\u0438\u043c\u044b\u0439<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">Moderate \u2014 Canani 2011; Sossai 2019; Ramirez-Garcia 2021<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u041f\u0440\u0435\u0434\u043f\u043e\u0447\u0442\u0438\u0442\u0435\u043b\u044c\u043d\u0430 \u043a\u0438\u0448\u0435\u0447\u043d\u043e\u0440\u0430\u0441\u0442\u0432\u043e\u0440\u0438\u043c\u0430\u044f \u0444\u043e\u0440\u043c\u0430; \u044d\u043d\u0434\u043e\u0433\u0435\u043d\u043d\u044b\u0439 \u0438\u0437 \u043f\u0438\u0449\u0438 (\u043e\u0445\u043b\u0430\u0436\u0434\u0451\u043d\u043d\u044b\u0439 \u043a\u0430\u0440\u0442\u043e\u0444\u0435\u043b\u044c, \u043e\u0432\u0451\u0441, \u0431\u043e\u0431\u043e\u0432\u044b\u0435)<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u0412\u0438\u0442\u0430\u043c\u0438\u043d D3 (\u0445\u043e\u043b\u0435\u043a\u0430\u043b\u044c\u0446\u0438\u0444\u0435\u0440\u043e\u043b)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u041a\u043b\u0430\u0443\u0434\u0438\u043d-5, \u043e\u043a\u043a\u043b\u044e\u0434\u0438\u043d; \u2193NF-\u03baB \u2192 \u2193\u0446\u0438\u0442\u043e\u043a\u0438\u043d\u044b<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">VDR-\u044f\u0434\u0435\u0440\u043d\u044b\u0439 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440 \u2192 \u2191\u0442\u0440\u0430\u043d\u0441\u043a\u0440\u0438\u043f\u0446\u0438\u044f CLDN5, OCLN; \u2193TNF-\u03b1 \u0438 IL-1\u03b2 \u2192 \u043a\u043e\u0441\u0432\u0435\u043d\u043d\u0430\u044f \u0437\u0430\u0449\u0438\u0442\u0430 TJ<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">2000\u20134000 \u041c\u0415\/\u0441\u0443\u0442 (\u0446\u0435\u043b\u044c 25OHD: 50\u201380 \u043d\u0433\/\u043c\u043b)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">Moderate-High \u2014 Kong 2020; Rosen 2012; Tabatabaeizadeh 2019<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u041a\u043e\u043d\u0442\u0440\u043e\u043b\u044c \u043a\u0430\u043b\u044c\u0446\u0438\u044f \u043f\u0440\u0438 >4000 \u041c\u0415\/\u0441\u0443\u0442; \u0434\u0435\u0444\u0438\u0446\u0438\u0442 D \u043a\u0440\u0430\u0439\u043d\u0435 \u0440\u0430\u0441\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0451\u043d \u0432 \u0420\u0424 (70% \u043f\u043e\u043f\u0443\u043b\u044f\u0446\u0438\u0438 &lt;30 \u043d\u0433\/\u043c\u043b)<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u0426\u0438\u043d\u043a (\u0431\u0438\u0441\u0433\u043b\u0438\u0446\u0438\u043d\u0430\u0442 \u0438\u043b\u0438 \u043f\u0438\u043a\u043e\u043b\u0438\u043d\u0430\u0442)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">ZO-1, \u043e\u043a\u043a\u043b\u044e\u0434\u0438\u043d \u043d\u0430 \u0443\u0440\u043e\u0432\u043d\u0435 \u043c\u0420\u041d\u041a<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u2191\u044d\u043a\u0441\u043f\u0440\u0435\u0441\u0441\u0438\u044f TJ-\u0433\u0435\u043d\u043e\u0432 (ZO-1, OCLN) \u0447\u0435\u0440\u0435\u0437 Zn-\u0437\u0430\u0432\u0438\u0441\u0438\u043c\u044b\u0435 \u0442\u0440\u0430\u043d\u0441\u043a\u0440\u0438\u043f\u0446\u0438\u043e\u043d\u043d\u044b\u0435 \u0444\u0430\u043a\u0442\u043e\u0440\u044b; \u0430\u043d\u0442\u0438\u043e\u043a\u0441\u0438\u0434\u0430\u043d\u0442 (Cu-Zn-\u0421\u041e\u0414)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">25\u201340 \u043c\u0433\/\u0441\u0443\u0442 (\u043d\u0435 >40 \u043c\u0433)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">Low-Moderate \u2014 Wang 2019; Sturniolo 2001 (\u0412\u0417\u041a)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u0414\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0439 \u043f\u0440\u0438\u0451\u043c (>3 \u043c\u0435\u0441.) \u2192 \u0440\u0438\u0441\u043a \u0434\u0435\u0444\u0438\u0446\u0438\u0442\u0430 \u043c\u0435\u0434\u0438; \u0444\u043e\u0440\u043c\u0430 \u0431\u0438\u0441\u0433\u043b\u0438\u0446\u0438\u043d\u0430\u0442 \u0431\u0438\u043e\u0434\u043e\u0441\u0442\u0443\u043f\u043d\u0435\u0435 \u043e\u043a\u0441\u0438\u0434\u0430<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u041a\u0432\u0435\u0440\u0446\u0435\u0442\u0438\u043d<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">MLCK-\u0438\u043d\u0433\u0438\u0431\u0438\u0442\u043e\u0440; \u2193NF-\u03baB \u2192 \u2193TNF-\u03b1, IL-1\u03b2<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u041a\u043e\u043d\u043a\u0443\u0440\u0435\u043d\u0442\u043d\u044b\u0439 \u0438\u043d\u0433\u0438\u0431\u0438\u0442\u043e\u0440 MLCK \u2192 \u2193\u0444\u043e\u0441\u0444\u043e-MLC20 \u2192 \u2193\u043c\u0435\u0445\u0430\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u043e\u0442\u043a\u0440\u044b\u0442\u0438\u0435 TJ; \u2193NF-\u03baB \u2192 \u043c\u0435\u043d\u044c\u0448\u0435 \u043f\u0440\u043e\u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442. \u0446\u0438\u0442\u043e\u043a\u0438\u043d\u043e\u0432<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">500\u20131000 \u043c\u0433\/\u0441\u0443\u0442 (\u0441 \u0436\u0438\u0440\u0430\u043c\u0438 \u0434\u043b\u044f \u0431\u0438\u043e\u0434\u043e\u0441\u0442\u0443\u043f\u043d\u043e\u0441\u0442\u0438)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">Low-Moderate \u2014 Suzuki 2009 (in vitro + animal); Amasheh 2008<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u0412\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u0441 CYP3A4\/CYP2C9 \u2014 \u043e\u0441\u0442\u043e\u0440\u043e\u0436\u043d\u043e \u043f\u0440\u0438 \u0441\u0442\u0430\u0442\u0438\u043d\u0430\u0445, \u0432\u0430\u0440\u0444\u0430\u0440\u0438\u043d\u0435; \u0444\u0438\u0442\u043e\u0441\u043e\u043c\u043d\u0430\u044f \u0444\u043e\u0440\u043c\u0430 \u043b\u0443\u0447\u0448\u0435 \u0443\u0441\u0432\u0430\u0438\u0432\u0430\u0435\u0442\u0441\u044f<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u0411\u0435\u0440\u0431\u0435\u0440\u0438\u043d<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">MLCK-\u0438\u043d\u0433\u0438\u0431\u0438\u0442\u043e\u0440; \u2191AMPK; \u2193NF-\u03baB<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u0418\u043d\u0433\u0438\u0431\u0438\u0440\u0443\u0435\u0442 MLCK \u043d\u0430\u043f\u0440\u044f\u043c\u0443\u044e + \u0447\u0435\u0440\u0435\u0437 \u2191AMPK \u2192 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0431\u0430\u0440\u044c\u0435\u0440\u043d\u0430\u044f \u0437\u0430\u0449\u0438\u0442\u0430; \u2193TNF-\u03b1, IL-6<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">500 \u043c\u0433 2\u20133 \u0440\/\u0441\u0443\u0442 (\u0441 \u0435\u0434\u043e\u0439)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">Moderate \u2014 Gu 2020 (\u043f\u0440\u0438 \u0421\u0414 2 \u0438 \u041f\u041a\u041f); Zhang 2010<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u2193CYP3A4 \u2014 \u0432\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u0441 \u043c\u0435\u0442\u0444\u043e\u0440\u043c\u0438\u043d\u043e\u043c, \u0441\u0442\u0430\u0442\u0438\u043d\u0430\u043c\u0438; \u0433\u0438\u043f\u043e\u0433\u043b\u0438\u043a\u0435\u043c\u0438\u044f \u043f\u0440\u0438 \u043a\u043e\u043c\u0431\u0438\u043d\u0430\u0446\u0438\u0438 \u0441 \u041f\u0421\u041c<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u0418\u043d\u0434\u043e\u043b-3-\u043a\u0430\u0440\u0431\u0438\u043d\u043e\u043b (I3C) \/ DIM<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u041a\u043b\u0430\u0443\u0434\u0438\u043d-5; IEL (\u0438\u043d\u0442\u0440\u0430\u044d\u043f\u0438\u0442. \u043b\u0438\u043c\u0444\u043e\u0446\u0438\u0442\u044b)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">AhR-\u0430\u0433\u043e\u043d\u0438\u0441\u0442 \u2192 \u2191\u0442\u0440\u0430\u043d\u0441\u043a\u0440\u0438\u043f\u0446\u0438\u044f CLDN5; \u2191IEL-\u0444\u0443\u043d\u043a\u0446\u0438\u044e \u2192 \u0438\u043c\u043c\u0443\u043d\u043d\u0430\u044f \u0437\u0430\u0449\u0438\u0442\u0430 \u0441\u043b\u0438\u0437\u0438\u0441\u0442\u043e\u0439<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">I3C 200\u2013400 \u043c\u0433\/\u0441\u0443\u0442; DIM 100\u2013200 \u043c\u0433\/\u0441\u0443\u0442<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">Low (in vitro + animal \u2014 Kiss 2011; Montrose 2015)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u041f\u0438\u0449\u0435\u0432\u044b\u0435 \u0438\u0441\u0442\u043e\u0447\u043d\u0438\u043a\u0438: \u0431\u0440\u043e\u043a\u043a\u043e\u043b\u0438, \u0431\u0440\u044e\u0441\u0441\u0435\u043b\u044c\u0441\u043a\u0430\u044f \u043a\u0430\u043f\u0443\u0441\u0442\u0430, \u043a\u0430\u043b\u0435; \u043e\u0441\u0442\u043e\u0440\u043e\u0436\u043d\u043e \u043f\u0440\u0438 \u0433\u043e\u0440\u043c\u043e\u043d\u043e\u0437\u0430\u0432\u0438\u0441\u0438\u043c\u044b\u0445 \u043e\u043f\u0443\u0445\u043e\u043b\u044f\u0445<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u041a\u0443\u0440\u043a\u0443\u043c\u0438\u043d (\u0431\u0438\u043e\u043f\u0435\u0440\u0438\u043d-\u0443\u0441\u0438\u043b\u0435\u043d\u043d\u044b\u0439)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">NF-\u03baB, TNF-\u03b1, IL-1\u03b2 \u2192 TJ \u0437\u0430\u0449\u0438\u0442\u0430<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u041f\u043b\u0435\u0439\u043e\u0442\u0440\u043e\u043f\u043d\u044b\u0439 \u0438\u043d\u0433\u0438\u0431\u0438\u0442\u043e\u0440 NF-\u03baB \u2192 \u2193\u0446\u0438\u0442\u043e\u043a\u0438\u043d\u043e\u0432\u0430\u044f \u0430\u0433\u0440\u0435\u0441\u0441\u0438\u044f \u043d\u0430 TJ-\u0431\u0435\u043b\u043a\u0438; \u2191Nrf2 \u2192 \u0430\u043d\u0442\u0438\u043e\u043a\u0441\u0438\u0434\u0430\u043d\u0442<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">500\u20131000 \u043c\u0433\/\u0441\u0443\u0442 (\u0441 \u043f\u0438\u043f\u0435\u0440\u0438\u043d\u043e\u043c 5\u201310 \u043c\u0433)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">Low-Moderate \u2014 Ghaffari 2021; Bereswill 2010<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u0411\u0438\u043e\u0434\u043e\u0441\u0442\u0443\u043f\u043d\u043e\u0441\u0442\u044c \u0441\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u043e\u0433\u043e \u043a\u0443\u0440\u043a\u0443\u043c\u0438\u043d\u0430 \u043a\u0440\u0430\u0439\u043d\u0435 \u043d\u0438\u0437\u043a\u0430\u044f (~1%); \u0442\u0440\u0435\u0431\u0443\u0435\u0442 \u0444\u043e\u0440\u043c\u044b \u0441 \u043f\u0438\u043f\u0435\u0440\u0438\u043d\u043e\u043c, \u043b\u0435\u0446\u0438\u0442\u0438\u043d\u043e\u043c \u0438\u043b\u0438 \u043d\u0430\u043d\u043e\u043a\u0430\u043f\u0441\u0443\u043b<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u041e\u043c\u0435\u0433\u0430-3 (EPA\/DHA)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u041a\u043b\u0430\u0443\u0434\u0438\u043d-1, \u043a\u043b\u0430\u0443\u0434\u0438\u043d-5 (\u0447\u0435\u0440\u0435\u0437 SPM)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u0421\u0438\u043d\u0442\u0435\u0437 \u0441\u043f\u0435\u0446\u0438\u0430\u043b\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0445 \u043f\u0440\u043e-\u0440\u0435\u0437\u043e\u043b\u044e\u0446\u0438\u043e\u043d\u043d\u044b\u0445 \u043c\u0435\u0434\u0438\u0430\u0442\u043e\u0440\u043e\u0432 (SPM: \u0440\u0435\u0437\u043e\u043b\u0432\u0438\u043d\u044b, \u043f\u0440\u043e\u0442\u0435\u043a\u0442\u0438\u043d\u044b) \u2192 \u2193TNF-\u03b1, IL-1\u03b2 \u2192 \u043a\u043e\u0441\u0432\u0435\u043d\u043d\u0430\u044f \u0437\u0430\u0449\u0438\u0442\u0430 TJ<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">1000\u20133000 \u043c\u0433 EPA+DHA\/\u0441\u0443\u0442<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">Moderate \u2014 RCT \u043f\u0440\u0438 \u0412\u0417\u041a; in vitro TJ-\u0434\u0430\u043d\u043d\u044b\u0435<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u0420\u0438\u0441\u043a \u043a\u0440\u043e\u0432\u043e\u0442\u0435\u0447\u0435\u043d\u0438\u0439 \u043f\u0440\u0438 >3 \u0433\/\u0441\u0443\u0442; \u0432\u0437\u0430\u0438\u043c\u043e\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435 \u0441 \u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u0430\u043c\u0438<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u041c\u0430\u0433\u043d\u0438\u0439 (\u0433\u043b\u0438\u0446\u0438\u043d\u0430\u0442\/\u0442\u0440\u0435\u043e\u043d\u0430\u0442)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">MLCK-\u043a\u043e\u0444\u0430\u043a\u0442\u043e\u0440 (\u0440\u0435\u0433\u0443\u043b\u044f\u0446\u0438\u044f Mg-ATP)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">Mg\u00b2\u207a \u2014 \u043a\u043e\u0444\u0430\u043a\u0442\u043e\u0440 MLCK; \u0434\u0435\u0444\u0438\u0446\u0438\u0442 \u2192 \u2191MLCK-\u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c \u2192 \u2191\u043e\u0442\u043a\u0440\u044b\u0442\u0438\u0435 TJ; Mg\u2191 \u2192 \u2193MLCK-\u0437\u0430\u0432\u0438\u0441\u0438\u043c\u0430\u044f \u041f\u041a\u041f<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">300\u2013400 \u043c\u0433\/\u0441\u0443\u0442<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">Low \u2014 \u043c\u0435\u0445\u0430\u043d\u0438\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0434\u0430\u043d\u043d\u044b\u0435; Moderate \u0434\u043b\u044f \u0434\u0435\u0444\u0438\u0446\u0438\u0442\u0430<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u041d\u0430\u0438\u0431\u043e\u043b\u0435\u0435 \u0431\u0438\u043e\u0434\u043e\u0441\u0442\u0443\u043f\u043d\u044b \u0433\u043b\u0438\u0446\u0438\u043d\u0430\u0442 \u0438 \u0442\u0440\u0435\u043e\u043d\u0430\u0442; \u043e\u043a\u0441\u0438\u0434 \u043c\u0430\u0433\u043d\u0438\u044f \u043f\u043b\u043e\u0445\u043e \u0443\u0441\u0432\u0430\u0438\u0432\u0430\u0435\u0442\u0441\u044f<\/td><\/tr><\/tbody><\/table><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-682819a0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"682819a0\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3c6ab534\" data-id=\"3c6ab534\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b61cad5 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"b61cad5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4f26b5f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4f26b5f\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-64f2450\" data-id=\"64f2450\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-177cf0c2 elementor-widget elementor-widget-heading\" data-id=\"177cf0c2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">6. \u041f\u0440\u043e\u0442\u043e\u043a\u043e\u043b \u0432\u043e\u0441\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u0438\u044f Tight Junctions \u2014 \u043f\u043e\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u044c \u0438 \u043c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-36f38151 elementor-widget elementor-widget-text-editor\" data-id=\"36f38151\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"background:#FFFBEB;border-left:4px solid #D97706;border-radius:0 8px 8px 0;padding:16px 20px;margin-bottom:16px;\"><b>\u0412\u0430\u0436\u043d\u043e:<\/b> \u043f\u0440\u043e\u0442\u043e\u043a\u043e\u043b \u043d\u0435 \u0437\u0430\u043c\u0435\u043d\u044f\u0435\u0442 \u0443\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u0438\u0435 \u043f\u0435\u0440\u0432\u043e\u043f\u0440\u0438\u0447\u0438\u043d\u044b (\u0434\u0438\u0441\u0431\u0438\u043e\u0437, \u0433\u043b\u044e\u0442\u0435\u043d, \u041d\u041f\u0412\u0421). \u041d\u0443\u0442\u0440\u0438\u0446\u0435\u0432\u0442\u0438\u043a\u0438 \u2014 \u043f\u043e\u0434\u0434\u0435\u0440\u0436\u0438\u0432\u0430\u044e\u0449\u0438\u0439, \u0430 \u043d\u0435 \u043e\u0441\u043d\u043e\u0432\u043d\u043e\u0439 \u0438\u043d\u0441\u0442\u0440\u0443\u043c\u0435\u043d\u0442. \u041d\u0430\u0437\u043d\u0430\u0447\u0430\u0435\u0442\u0441\u044f \u0438 \u043a\u043e\u0440\u0440\u0435\u043a\u0442\u0438\u0440\u0443\u0435\u0442\u0441\u044f \u0441\u043e\u0432\u043c\u0435\u0441\u0442\u043d\u043e \u0441 \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u043e\u043c.<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5bb2f929 elementor-widget elementor-widget-html\" data-id=\"5bb2f929\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<div style=\"overflow-x:auto;margin-bottom:20px;\"><table style=\"width:100%;border-collapse:collapse;font-family:Arial,sans-serif;\"><thead><tr><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u0424\u0430\u0437\u0430<\/th><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u0414\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u044c<\/th><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u041a\u043b\u044e\u0447\u0435\u0432\u044b\u0435 \u0438\u043d\u0442\u0435\u0440\u0432\u0435\u043d\u0446\u0438\u0438<\/th><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u0426\u0435\u043b\u044c<\/th><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u041a\u043e\u043d\u0442\u0440\u043e\u043b\u044c<\/th><\/tr><\/thead><tbody><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u0424\u0430\u0437\u0430 1: \u0423\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u0438\u0435 \u0442\u0440\u0438\u0433\u0433\u0435\u0440\u043e\u0432<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">1\u20132 \u043d\u0435\u0434\u0435\u043b\u0438<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u0418\u0441\u043a\u043b\u044e\u0447\u0438\u0442\u044c \u0433\u043b\u044e\u0442\u0435\u043d (\u043f\u0440\u0438 \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u044f\u0445), \u041d\u041f\u0412\u0421\u2192\u0430\u043b\u044c\u0442\u0435\u0440\u043d\u0430\u0442\u0438\u0432\u044b, \u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044c\u21920; \u043d\u0430\u0447\u0430\u0442\u044c \u0441\u0442\u0440\u0435\u0441\u0441-\u043c\u0435\u043d\u0435\u0434\u0436\u043c\u0435\u043d\u0442<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u041f\u0440\u0435\u043a\u0440\u0430\u0442\u0438\u0442\u044c \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0435 \u0440\u0430\u0437\u0440\u0443\u0448\u0435\u043d\u0438\u0435 TJ<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u0414\u043d\u0435\u0432\u043d\u0438\u043a \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u043e\u0432<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u0424\u0430\u0437\u0430 2: \u041f\u0440\u043e\u0442\u0438\u0432\u043e\u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u0430\u044f \u0431\u0430\u0437\u0430<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">4\u20138 \u043d\u0435\u0434\u0435\u043b\u044c<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u0412\u0438\u0442\u0430\u043c\u0438\u043d D3 (2000\u20134000 \u041c\u0415\/\u0441\u0443\u0442, \u0446\u0435\u043b\u044c 50\u201380 \u043d\u0433\/\u043c\u043b) + \u041e\u043c\u0435\u0433\u0430-3 (2000 \u043c\u0433 EPA+DHA) + \u043f\u0440\u043e\u0431\u0438\u043e\u0442\u0438\u043a (LGG \u0438\u043b\u0438 VSL#3)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u2193TNF-\u03b1, IL-1\u03b2 \u2192 \u043a\u043e\u0441\u0432\u0435\u043d\u043d\u0430\u044f \u0437\u0430\u0449\u0438\u0442\u0430 TJ; \u0432\u043e\u0441\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u0438\u0435 \u043c\u0438\u043a\u0440\u043e\u0431\u0438\u043e\u043c\u0430<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">25OHD \u0447\u0435\u0440\u0435\u0437 4 \u043d\u0435\u0434.; \u0437\u043e\u043d\u0443\u043b\u0438\u043d-\u0442\u0435\u0441\u0442 (\u0431\u0430\u0437\u043e\u0432\u044b\u0439)<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u0424\u0430\u0437\u0430 3: \u041f\u0440\u044f\u043c\u0430\u044f \u043f\u043e\u0434\u0434\u0435\u0440\u0436\u043a\u0430 TJ<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">8\u201316 \u043d\u0435\u0434\u0435\u043b\u044c<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u0411\u0443\u0442\u0438\u0440\u0430\u0442 \u043d\u0430\u0442\u0440\u0438\u044f 300\u2013600 \u043c\u0433 + L-\u0433\u043b\u0443\u0442\u0430\u043c\u0438\u043d 5\u201310 \u0433 + \u0446\u0438\u043d\u043a (\u0431\u0438\u0441\u0433\u043b\u0438\u0446\u0438\u043d\u0430\u0442) 25\u201340 \u043c\u0433 + \u043a\u0432\u0435\u0440\u0446\u0435\u0442\u0438\u043d 500\u20131000 \u043c\u0433<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u2191ZO-1, \u043e\u043a\u043a\u043b\u044e\u0434\u0438\u043d, \u043a\u043b\u0430\u0443\u0434\u0438\u043d\u044b \u0447\u0435\u0440\u0435\u0437 \u0440\u0430\u0437\u043d\u044b\u0435 \u043f\u0443\u0442\u0438; MLCK-\u0438\u043d\u0433\u0438\u0431\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u041f\u043e\u0432\u0442\u043e\u0440\u043d\u044b\u0439 \u0437\u043e\u043d\u0443\u043b\u0438\u043d \u0447\u0435\u0440\u0435\u0437 12 \u043d\u0435\u0434.; \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u043d\u0430\u044f \u0448\u043a\u0430\u043b\u0430<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u0424\u0430\u0437\u0430 4: \u041f\u043e\u0434\u0434\u0435\u0440\u0436\u0438\u0432\u0430\u044e\u0449\u0430\u044f<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u0414\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u043e<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u0421\u0440\u0435\u0434\u0438\u0437\u0435\u043c\u043d\u043e\u043c\u043e\u0440\u0441\u043a\u0430\u044f \u0434\u0438\u0435\u0442\u0430, \u0444\u0435\u0440\u043c\u0435\u043d\u0442\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0435 \u043f\u0440\u043e\u0434\u0443\u043a\u0442\u044b, \u0432\u0438\u0442\u0430\u043c\u0438\u043d D \u043f\u0440\u043e\u0444\u0438\u043b\u0430\u043a\u0442\u0438\u0447\u0435\u0441\u043a\u0438, \u043f\u0440\u0435\u0431\u0438\u043e\u0442\u0438\u043a\u0438 (\u0438\u043d\u0443\u043b\u0438\u043d 5\u201310 \u0433\/\u0441\u0443\u0442)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u041f\u043e\u0434\u0434\u0435\u0440\u0436\u0430\u043d\u0438\u0435 \u0432\u043e\u0441\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u043d\u043e\u0433\u043e \u0431\u0430\u0440\u044c\u0435\u0440\u0430<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u0417\u043e\u043d\u0443\u043b\u0438\u043d 1 \u0440\/\u0433\u043e\u0434; LBP \u043f\u0440\u0438 \u0443\u0445\u0443\u0434\u0448\u0435\u043d\u0438\u0438 \u0441\u0438\u043c\u043f\u0442\u043e\u043c\u043e\u0432<\/td><\/tr><\/tbody><\/table><\/div>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5665b536 elementor-widget elementor-widget-heading\" data-id=\"5665b536\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">\u041e\u0436\u0438\u0434\u0430\u0435\u043c\u0430\u044f \u0434\u0438\u043d\u0430\u043c\u0438\u043a\u0430 \u0437\u043e\u043d\u0443\u043b\u0438\u043d\u0430<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3252e7a6 elementor-widget elementor-widget-html\" data-id=\"3252e7a6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<div style=\"overflow-x:auto;margin-bottom:20px;\"><table style=\"width:100%;border-collapse:collapse;font-family:Arial,sans-serif;\"><thead><tr><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u0418\u043d\u0442\u0435\u0440\u0432\u0430\u043b<\/th><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u041e\u0436\u0438\u0434\u0430\u0435\u043c\u043e\u0435 \u0441\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u0437\u043e\u043d\u0443\u043b\u0438\u043d\u0430<\/th><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u0418\u0441\u0442\u043e\u0447\u043d\u0438\u043a<\/th><\/tr><\/thead><tbody><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">4 \u043d\u0435\u0434\u0435\u043b\u0438<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">10\u201320% (\u043f\u0440\u0438 \u0443\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u0438\u0438 \u0433\u043b\u044e\u0442\u0435\u043d\u0430 \u0443 \u041d\u0426\u0413\u0427)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">Drago 2006; Fasano data<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">8 \u043d\u0435\u0434\u0435\u043b\u044c<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">20\u201335% (\u043f\u0440\u0438 \u043f\u0440\u043e\u0431\u0438\u043e\u0442\u0438\u043a\u0430\u0445 + \u0434\u0438\u0435\u0442\u0435)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">RCT \u0438\u0437 \u043c\u0435\u0442\u0430-\u0430\u043d\u0430\u043b\u0438\u0437\u0430 Ghorbani 2025<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">12 \u043d\u0435\u0434\u0435\u043b\u044c<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">30\u201350% (\u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u043d\u044b\u0439 \u043f\u0440\u043e\u0442\u043e\u043a\u043e\u043b)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">Ghorbani 2025 (SMD \u22120.49 = ~35\u201350% \u043e\u0442 \u0438\u0441\u0445.)<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">24 \u043d\u0435\u0434\u0435\u043b\u0438<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">50\u201370% (\u043f\u0440\u0438 \u043f\u043e\u043b\u043d\u043e\u043c \u0443\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u0438\u0438 \u0442\u0440\u0438\u0433\u0433\u0435\u0440\u043e\u0432)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u041a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0435 \u0434\u0430\u043d\u043d\u044b\u0435 RCT; case series<\/td><\/tr><\/tbody><\/table><\/div>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d6653fe elementor-widget elementor-widget-text-editor\" data-id=\"d6653fe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"background: #F0F9FF; border: 1px solid #BAE6FD; border-radius: 8px; padding: 12px 18px; margin-bottom: 10px;\"><p><span style=\"color: #0284c7; font-size: 15px; font-weight: 600;\">\u2192 <\/span><a style=\"color: #0284c7; font-size: 15px; font-weight: 600; text-decoration: none;\" href=\"https:\/\/novolakrb1.ru\/statii\/zonulin-analiz-normy\/\">\u0417\u043e\u043d\u0443\u043b\u0438\u043d-\u0442\u0435\u0441\u0442: \u043a\u0430\u043a \u043e\u0442\u0441\u043b\u0435\u0436\u0438\u0432\u0430\u0442\u044c \u0434\u0438\u043d\u0430\u043c\u0438\u043a\u0443 \u0432\u043e\u0441\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u0438\u044f TJ<\/a><\/p><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7200617d elementor-widget elementor-widget-text-editor\" data-id=\"7200617d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"background: #F0F9FF; border: 1px solid #BAE6FD; border-radius: 8px; padding: 12px 18px; margin-bottom: 10px;\"><br \/><span style=\"color: #0284c7; font-size: 15px; font-weight: 600;\">\u2192 <\/span><a style=\"color: #0284c7; font-size: 15px; font-weight: 600; text-decoration: none;\" href=\"https:\/\/novolakrb1.ru\/statii\/mikrobiom-dyravyy-kishechnik\/\">\u041f\u0440\u043e\u0431\u0438\u043e\u0442\u0438\u043a\u0438 \u043a\u0430\u043a \u043e\u0441\u043d\u043e\u0432\u0430 \u0432\u043e\u0441\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u0438\u044f \u043c\u0438\u043a\u0440\u043e\u0431\u0438\u043e\u043c\u0437\u0430\u0432\u0438\u0441\u0438\u043c\u043e\u0433\u043e \u043f\u0443\u0442\u0438 TJ<\/a><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5d3b8896 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5d3b8896\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-506ddb14\" data-id=\"506ddb14\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-253770bd elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"253770bd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-74b62012 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"74b62012\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-505caf90\" data-id=\"505caf90\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-76c4015b elementor-widget elementor-widget-heading\" data-id=\"76c4015b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">7. \u041f\u0435\u0440\u0441\u043f\u0435\u043a\u0442\u0438\u0432\u043d\u044b\u0435 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044b: \u0431\u0443\u0434\u0443\u0449\u0435\u0435 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 Tight Junctions<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-196240d8 elementor-widget elementor-widget-text-editor\" data-id=\"196240d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p style=\"font-size:16px;line-height:1.75;color:#1E293B;margin:0 0 14px 0;\">\u0418\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f 2023\u20132026 \u0433\u043e\u0434\u043e\u0432 \u0443\u043a\u0430\u0437\u044b\u0432\u0430\u044e\u0442 \u043d\u0430 \u043d\u0435\u0441\u043a\u043e\u043b\u044c\u043a\u043e \u043f\u0435\u0440\u0441\u043f\u0435\u043a\u0442\u0438\u0432\u043d\u044b\u0445 \u043d\u0430\u043f\u0440\u0430\u0432\u043b\u0435\u043d\u0438\u0439, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u0435\u0449\u0451 \u043d\u0435 \u0432\u043e\u0448\u043b\u0438 \u0432 \u0441\u0442\u0430\u043d\u0434\u0430\u0440\u0442\u043d\u0443\u044e \u043f\u0440\u0430\u043a\u0442\u0438\u043a\u0443, \u043d\u043e \u0438\u043c\u0435\u044e\u0442 \u0443\u0431\u0435\u0434\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0435 \u0434\u043e\u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0434\u0430\u043d\u043d\u044b\u0435:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2723b5a1 elementor-widget elementor-widget-html\" data-id=\"2723b5a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<div style=\"overflow-x:auto;margin-bottom:20px;\"><table style=\"width:100%;border-collapse:collapse;font-family:Arial,sans-serif;\"><thead><tr><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u041c\u043e\u043b\u0435\u043a\u0443\u043b\u0430\/\u043f\u043e\u0434\u0445\u043e\u0434<\/th><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u041c\u0435\u0445\u0430\u043d\u0438\u0437\u043c<\/th><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u0421\u0442\u0430\u0442\u0443\u0441 (2026)<\/th><th style=\"background:#DBEAFE;color:#1E3A8A;font-weight:700;font-size:13px;padding:10px 12px;text-align:left;border:1px solid #93C5FD;white-space:nowrap;\">\u041f\u0435\u0440\u0441\u043f\u0435\u043a\u0442\u0438\u0432\u0430<\/th><\/tr><\/thead><tbody><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">Larazotide acetate (AT-1001)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u0410\u043d\u0442\u0430\u0433\u043e\u043d\u0438\u0441\u0442 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u0430 \u0437\u043e\u043d\u0443\u043b\u0438\u043d\u0430 \u2192 \u0431\u043b\u043e\u043a\u0438\u0440\u0443\u0435\u0442 EGF-R \u0437\u0430\u0432\u0438\u0441\u0438\u043c\u044b\u0439 \u043f\u0443\u0442\u044c<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u0424\u0430\u0437\u0430 III \u043f\u0440\u0438 \u0446\u0435\u043b\u0438\u0430\u043a\u0438\u0438 (ClinicalTrials); \u043d\u0435 \u043e\u0434\u043e\u0431\u0440\u0435\u043d FDA<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u041f\u0435\u0440\u0432\u044b\u0439 \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u0435\u0441\u043a\u0438\u0439 anti-zonulin \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442; \u043e\u0436\u0438\u0434\u0430\u0435\u0442\u0441\u044f \u043e\u0434\u043e\u0431\u0440\u0435\u043d\u0438\u0435 2027\u20132028<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u041f\u0430\u0441\u0442\u0435\u0440\u0438\u0437\u043e\u0432\u0430\u043d\u043d\u0430\u044f Akkermansia muciniphila (WB-STR-0001)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u2191MUC2, \u2191TJ, \u2191GLP-1; \u044d\u0444\u0444\u0435\u043a\u0442 \u0441\u043e\u0445\u0440\u0430\u043d\u044f\u0435\u0442\u0441\u044f \u043f\u043e\u0441\u043b\u0435 \u0438\u043d\u0430\u043a\u0442\u0438\u0432\u0430\u0446\u0438\u0438 \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0438<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">RCT Depommier 2021 (n=40); \u0415\u0432\u0440\u043e\u043f\u0435\u0439\u0441\u043a\u0430\u044f \u0440\u0435\u0433\u0438\u0441\u0442\u0440\u0430\u0446\u0438\u044f \u043f\u043e\u0441\u0442\u0431\u0438\u043e\u0442\u0438\u043a\u0430 (2023)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u041f\u0435\u0440\u0432\u044b\u0439 \u0437\u0430\u0440\u0435\u0433\u0438\u0441\u0442\u0440\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0439 \u043f\u043e\u0441\u0442\u0431\u0438\u043e\u0442\u0438\u043a; \u0440\u0430\u0441\u0448\u0438\u0440\u0435\u043d\u0438\u0435 \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u0439<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u041f\u043e\u0441\u0442\u0431\u0438\u043e\u0442\u0438\u043a\u0438 \u2014 \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u044b\u0435 \u0432\u043d\u0435\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u044b\u0435 \u0432\u0435\u0437\u0438\u043a\u0443\u043b\u044b (EVs)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">EVs \u0438\u0437 Lactobacillus \u043d\u0435\u0441\u0443\u0442 \u0441\u0438\u0433\u043d\u0430\u043b\u044c\u043d\u044b\u0435 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044b \u2192 \u2191TJ-\u0433\u0435\u043d\u044b \u0431\u0435\u0437 \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u043e\u0441\u0442\u0438 \u0432 \u0436\u0438\u0432\u044b\u0445 \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u044f\u0445<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u0410\u043a\u0442\u0438\u0432\u043d\u044b\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f; \u0444\u0430\u0437\u0430 I\/II (ISAPP \u043a\u043e\u043d\u0441\u0435\u043d\u0441\u0443\u0441 2024)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u0421\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u044c, \u043e\u0442\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u0435 \u0440\u0438\u0441\u043a\u0430 \u0436\u0438\u0432\u044b\u0445 \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0439; \u0438\u0434\u0435\u0430\u043b\u044c\u043d\u043e \u0434\u043b\u044f \u0438\u043c\u043c\u0443\u043d\u043e\u043a\u043e\u043c\u043f\u0440\u043e\u043c\u0435\u0442\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0445<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">MLCK-\u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043f\u0435\u043f\u0442\u0438\u0434\u043d\u044b\u0435 \u0438\u043d\u0433\u0438\u0431\u0438\u0442\u043e\u0440\u044b (PIK)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u041f\u0440\u043e\u043d\u0438\u043a\u0430\u044e\u0449\u0438\u0435 \u0432 \u043a\u043b\u0435\u0442\u043a\u0443 \u043f\u0435\u043f\u0442\u0438\u0434\u044b, \u0431\u043b\u043e\u043a\u0438\u0440\u0443\u044e\u0449\u0438\u0435 MLCK \u0431\u0435\u0437 \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u044b\u0445 \u044d\u0444\u0444\u0435\u043a\u0442\u043e\u0432<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u0414\u043e\u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 (animal); \u0444\u0430\u0437\u0430 I \u043f\u043b\u0430\u043d\u0438\u0440\u0443\u0435\u0442\u0441\u044f 2026<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u0423\u0437\u043a\u043e\u0442\u0430\u0440\u0433\u0435\u0442\u043d\u0430\u044f \u0442\u0435\u0440\u0430\u043f\u0438\u044f \u0431\u0435\u0437 \u0440\u0438\u0441\u043a\u0430 \u0438\u043c\u043c\u0443\u043d\u043e\u0441\u0443\u043f\u0440\u0435\u0441\u0441\u0438\u0438; \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u0435 \u043f\u0440\u0438 \u0441\u0435\u043f\u0441\u0438\u0441\u0435, \u0412\u0417\u041a<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">FXR (Farnesoid X receptor) \u0430\u0433\u043e\u043d\u0438\u0441\u0442\u044b<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">FXR \u2192 \u2191TJ-\u0433\u0435\u043d\u044b (CLDN3, CLDN4); \u0436\u0435\u043b\u0447\u043d\u044b\u0435 \u043a\u0438\u0441\u043b\u043e\u0442\u044b \u0441\u0438\u0433\u043d\u0430\u043b\u0438\u0437\u0438\u0440\u0443\u044e\u0442 \u0447\u0435\u0440\u0435\u0437 FXR \u2192 \u0437\u0430\u0449\u0438\u0442\u0430 \u0431\u0430\u0440\u044c\u0435\u0440\u0430<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u041e\u0431\u0435\u0442\u0438\u0445\u043e\u043b\u043e\u0432\u0430\u044f \u043a\u0438\u0441\u043b\u043e\u0442\u0430 \u043e\u0434\u043e\u0431\u0440\u0435\u043d\u0430 \u043f\u0440\u0438 \u041f\u0421\u0425\/\u041d\u0410\u0416\u0411\u041f; TJ-\u044d\u0444\u0444\u0435\u043a\u0442\u044b \u043f\u043e\u0434\u0442\u0432\u0435\u0440\u0436\u0434\u0435\u043d\u044b in vivo<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#F8FAFC;vertical-align:top;line-height:1.5;\">\u0420\u0435\u0431\u043e\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435 \u0441\u0443\u0449\u0435\u0441\u0442\u0432\u0443\u044e\u0449\u0438\u0445 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0432 \u0434\u043b\u044f \u0442\u0435\u0440\u0430\u043f\u0438\u0438 leaky gut \u043f\u0440\u0438 \u041d\u0410\u0416\u0411\u041f<\/td><\/tr><tr><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u0422\u0430\u0440\u0433\u0435\u0442\u043d\u0430\u044f \u0434\u043e\u0441\u0442\u0430\u0432\u043a\u0430 \u0431\u0443\u0442\u0438\u0440\u0430\u0442\u0430 (\u043d\u0430\u043d\u043e\u043a\u0430\u043f\u0441\u0443\u043b\u044b, \u043f\u0440\u043e\u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0430)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u2191\u0431\u0438\u043e\u0434\u043e\u0441\u0442\u0443\u043f\u043d\u043e\u0441\u0442\u044c \u0431\u0443\u0442\u0438\u0440\u0430\u0442\u0430 \u0432 \u043f\u0440\u043e\u043a\u0441\u0438\u043c\u0430\u043b\u044c\u043d\u043e\u0439 \u043e\u0431\u043e\u0434\u043e\u0447\u043d\u043e\u0439 \u043a\u0438\u0448\u043a\u0435; \u043e\u0431\u0445\u043e\u0434 \u0430\u0431\u0441\u043e\u0440\u0431\u0446\u0438\u0438 \u0432 \u0442\u043e\u043d\u043a\u043e\u043c \u043a\u0438\u0448\u0435\u0447\u043d\u0438\u043a\u0435<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u0420\u0430\u0437\u0440\u0430\u0431\u043e\u0442\u043a\u0438; \u0440\u044f\u0434 \u0444\u043e\u0440\u043c\u0443\u043b \u0432\u044b\u0445\u043e\u0434\u0438\u0442 \u043d\u0430 \u0440\u044b\u043d\u043e\u043a (2025\u20132026)<\/td><td style=\"padding:9px 12px;border:1px solid #CBD5E1;font-size:13px;color:#1E293B;background:#FFFFFF;vertical-align:top;line-height:1.5;\">\u0420\u0435\u0448\u0430\u0435\u0442 \u043a\u043b\u044e\u0447\u0435\u0432\u0443\u044e \u043f\u0440\u043e\u0431\u043b\u0435\u043c\u0443 \u043e\u0440\u0430\u043b\u044c\u043d\u044b\u0445 \u0444\u043e\u0440\u043c \u0431\u0443\u0442\u0438\u0440\u0430\u0442\u0430 \u2014 \u043f\u0440\u0435\u0436\u0434\u0435\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u0430\u044f \u0430\u0431\u0441\u043e\u0440\u0431\u0446\u0438\u044f<\/td><\/tr><\/tbody><\/table><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-eb22ca4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"eb22ca4\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-48a94cb6\" data-id=\"48a94cb6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-216ce752 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"216ce752\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6b27ece4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6b27ece4\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-54ea1028\" data-id=\"54ea1028\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6c5802fe elementor-widget elementor-widget-heading\" data-id=\"6c5802fe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">FAQ \u2014 \u0427\u0430\u0441\u0442\u043e \u0437\u0430\u0434\u0430\u0432\u0430\u0435\u043c\u044b\u0435 \u0432\u043e\u043f\u0440\u043e\u0441\u044b<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5088c9e elementor-widget elementor-widget-text-editor\" data-id=\"5088c9e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div style=\"margin-bottom: 8px;\"><details style=\"border: 1px solid #CBD5E1; border-radius: 8px; margin-bottom: 8px; overflow: hidden;\"><summary style=\"font-size: 15px; font-weight: bold; color: #1e293b; padding: 14px 18px; cursor: pointer; background: #F8FAFC; list-style: none; display: flex; align-items: center; justify-content: space-between;\">\u0427\u0442\u043e \u0442\u0430\u043a\u043e\u0435 tight junctions \u043f\u0440\u043e\u0441\u0442\u044b\u043c\u0438 \u0441\u043b\u043e\u0432\u0430\u043c\u0438?<span style=\"font-size: 20px; color: #1e40af; font-weight: 300;\">+<\/span><\/summary><div style=\"padding: 14px 18px 16px; background: #FFFFFF; font-size: 15px; line-height: 1.7; color: #1e293b;\">Tight junctions \u2014 \u044d\u0442\u043e \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u044b\u0435 \u00ab\u0437\u0430\u043c\u043a\u0438\u00bb \u043c\u0435\u0436\u0434\u0443 \u043a\u043b\u0435\u0442\u043a\u0430\u043c\u0438 \u043a\u0438\u0448\u0435\u0447\u043d\u0438\u043a\u0430. \u041e\u043d\u0438 \u043a\u043e\u043d\u0442\u0440\u043e\u043b\u0438\u0440\u0443\u044e\u0442, \u0447\u0442\u043e \u043f\u0440\u043e\u0445\u043e\u0434\u0438\u0442 \u043c\u0435\u0436\u0434\u0443 \u043a\u043b\u0435\u0442\u043a\u0430\u043c\u0438 \u0432 \u043a\u0440\u043e\u0432\u043e\u0442\u043e\u043a. \u041a\u043e\u0433\u0434\u0430 \u0437\u0430\u043c\u043a\u0438 \u043b\u043e\u043c\u0430\u044e\u0442\u0441\u044f (\u0438\u0437-\u0437\u0430 \u0432\u043e\u0441\u043f\u0430\u043b\u0435\u043d\u0438\u044f, \u0441\u0442\u0440\u0435\u0441\u0441\u0430, \u0433\u043b\u044e\u0442\u0435\u043d\u0430, \u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044f), \u0442\u043e\u043a\u0441\u0438\u043d\u044b \u0438 \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u044b\u0435 \u0444\u0440\u0430\u0433\u043c\u0435\u043d\u0442\u044b \u043f\u043e\u043f\u0430\u0434\u0430\u044e\u0442 \u0432 \u043a\u0440\u043e\u0432\u044c \u2014 \u044d\u0442\u043e \u0438 \u0435\u0441\u0442\u044c \u0434\u044b\u0440\u044f\u0432\u044b\u0439 \u043a\u0438\u0448\u0435\u0447\u043d\u0438\u043a.<\/div><\/details><details style=\"border: 1px solid #CBD5E1; border-radius: 8px; margin-bottom: 8px; overflow: hidden;\"><summary style=\"font-size: 15px; font-weight: bold; color: #1e293b; padding: 14px 18px; cursor: pointer; background: #F8FAFC; list-style: none; display: flex; align-items: center; justify-content: space-between;\">\u041a\u0430\u043a\u043e\u0439 \u043d\u0443\u0442\u0440\u0438\u0435\u043d\u0442 \u043b\u0443\u0447\u0448\u0435 \u0432\u0441\u0435\u0433\u043e \u0432\u043e\u0441\u0441\u0442\u0430\u043d\u0430\u0432\u043b\u0438\u0432\u0430\u0435\u0442 tight junctions?<span style=\"font-size: 20px; color: #1e40af; font-weight: 300;\">+<\/span><\/summary><div style=\"padding: 14px 18px 16px; background: #FFFFFF; font-size: 15px; line-height: 1.7; color: #1e293b;\">\u041d\u0435\u0442 \u043e\u0434\u043d\u043e\u0433\u043e \u00ab\u043b\u0443\u0447\u0448\u0435\u0433\u043e\u00bb \u2014 \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u0435\u043d \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0439 \u043f\u0440\u043e\u0442\u043e\u043a\u043e\u043b. \u041f\u043e \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u044b\u043c \u043c\u0438\u0448\u0435\u043d\u044f\u043c: \u0431\u0443\u0442\u0438\u0440\u0430\u0442 \u0432\u043e\u0441\u0441\u0442\u0430\u043d\u0430\u0432\u043b\u0438\u0432\u0430\u0435\u0442 \u0447\u0435\u0440\u0435\u0437 \u044d\u043f\u0438\u0433\u0435\u043d\u0435\u0442\u0438\u043a\u0443 (HDAC), \u0432\u0438\u0442\u0430\u043c\u0438\u043d D \u2014 \u0447\u0435\u0440\u0435\u0437 VDR-\u0441\u0438\u0433\u043d\u0430\u043b\u0438\u043d\u0433, L-\u0433\u043b\u0443\u0442\u0430\u043c\u0438\u043d \u2014 \u043f\u0438\u0442\u0430\u0435\u0442 \u044d\u043d\u0442\u0435\u0440\u043e\u0446\u0438\u0442\u044b, \u0446\u0438\u043d\u043a \u2014 \u0447\u0435\u0440\u0435\u0437 \u0442\u0440\u0430\u043d\u0441\u043a\u0440\u0438\u043f\u0446\u0438\u044e \u043c\u0420\u041d\u041a ZO-1, \u043a\u0432\u0435\u0440\u0446\u0435\u0442\u0438\u043d \u2014 \u0438\u043d\u0433\u0438\u0431\u0438\u0440\u0443\u0435\u0442 MLCK. \u0412\u043c\u0435\u0441\u0442\u0435 \u043e\u043d\u0438 \u043f\u043e\u043a\u0440\u044b\u0432\u0430\u044e\u0442 \u0432\u0441\u0435 \u043e\u0441\u043d\u043e\u0432\u043d\u044b\u0435 \u043f\u0443\u0442\u0438.<\/div><\/details><details style=\"border: 1px solid #CBD5E1; border-radius: 8px; margin-bottom: 8px; overflow: hidden;\"><summary style=\"font-size: 15px; font-weight: bold; color: #1e293b; padding: 14px 18px; cursor: pointer; background: #F8FAFC; list-style: none; display: flex; align-items: center; justify-content: space-between;\">\u0421\u043a\u043e\u043b\u044c\u043a\u043e \u0432\u0440\u0435\u043c\u0435\u043d\u0438 \u0432\u043e\u0441\u0441\u0442\u0430\u043d\u0430\u0432\u043b\u0438\u0432\u0430\u0435\u0442\u0441\u044f ZO-1?<span style=\"font-size: 20px; color: #1e40af; font-weight: 300;\">+<\/span><\/summary><div style=\"padding: 14px 18px 16px; background: #FFFFFF; font-size: 15px; line-height: 1.7; color: #1e293b;\">\u041f\u043e \u0434\u0430\u043d\u043d\u044b\u043c RCT: \u0437\u043d\u0430\u0447\u0438\u043c\u043e\u0435 \u2191ZO-1 \u0444\u0438\u043a\u0441\u0438\u0440\u0443\u0435\u0442\u0441\u044f \u0447\u0435\u0440\u0435\u0437 8\u201312 \u043d\u0435\u0434\u0435\u043b\u044c \u043f\u0440\u0438 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u043d\u043e\u043c \u043f\u0440\u043e\u0442\u043e\u043a\u043e\u043b\u0435. \u0411\u0443\u0442\u0438\u0440\u0430\u0442 \u0434\u0430\u0451\u0442 \u044d\u0444\u0444\u0435\u043a\u0442 \u0431\u044b\u0441\u0442\u0440\u0435\u0435 (4\u20136 \u043d\u0435\u0434. \u0432 \u043d\u0435\u043a\u043e\u0442\u043e\u0440\u044b\u0445 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f\u0445). \u041f\u043e\u043b\u043d\u043e\u0435 \u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u043d\u043e\u0435 \u0432\u043e\u0441\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u0438\u0435 TJ \u2014 16\u201324 \u043d\u0435\u0434\u0435\u043b\u0438. \u041e\u0431\u044a\u0435\u043a\u0442\u0438\u0432\u043d\u044b\u0439 \u043a\u043e\u043d\u0442\u0440\u043e\u043b\u044c \u2014 \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u044b\u0439 \u0437\u043e\u043d\u0443\u043b\u0438\u043d-\u0442\u0435\u0441\u0442 \u0447\u0435\u0440\u0435\u0437 12 \u043d\u0435\u0434.<\/div><\/details><details style=\"border: 1px solid #CBD5E1; border-radius: 8px; margin-bottom: 8px; overflow: hidden;\"><summary style=\"font-size: 15px; font-weight: bold; color: #1e293b; padding: 14px 18px; cursor: pointer; background: #F8FAFC; list-style: none; display: flex; align-items: center; justify-content: space-between;\">\u041f\u043e\u043c\u043e\u0433\u0430\u0435\u0442 \u043b\u0438 L-\u0433\u043b\u0443\u0442\u0430\u043c\u0438\u043d \u043f\u0440\u0438 \u0434\u044b\u0440\u044f\u0432\u043e\u043c \u043a\u0438\u0448\u0435\u0447\u043d\u0438\u043a\u0435?<span style=\"font-size: 20px; color: #1e40af; font-weight: 300;\">+<\/span><\/summary><div style=\"padding: 14px 18px 16px; background: #FFFFFF; font-size: 15px; line-height: 1.7; color: #1e293b;\">\u0423\u043c\u0435\u0440\u0435\u043d\u043d\u0430\u044f \u0434\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c\u043d\u0430\u044f \u0431\u0430\u0437\u0430 (Moderate). \u0413\u043b\u0443\u0442\u0430\u043c\u0438\u043d \u2014 \u043e\u0441\u043d\u043e\u0432\u043d\u043e\u0439 \u044d\u043d\u0435\u0440\u0433\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0441\u0443\u0431\u0441\u0442\u0440\u0430\u0442 \u0434\u043b\u044f \u044d\u043d\u0442\u0435\u0440\u043e\u0446\u0438\u0442\u043e\u0432, \u0441\u0442\u0438\u043c\u0443\u043b\u0438\u0440\u0443\u0435\u0442 \u0441\u0438\u043d\u0442\u0435\u0437 ZO-1 \u0438 \u043a\u043b\u0430\u0443\u0434\u0438\u043d\u0430-5, \u043f\u043e\u0432\u044b\u0448\u0430\u0435\u0442 \u0433\u043b\u0443\u0442\u0430\u0442\u0438\u043e\u043d. RCT \u043f\u043e\u0434\u0442\u0432\u0435\u0440\u0436\u0434\u0430\u044e\u0442 \u044d\u0444\u0444\u0435\u043a\u0442 \u043f\u0440\u0438 \u043a\u0440\u0438\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0441\u043e\u0441\u0442\u043e\u044f\u043d\u0438\u044f\u0445 \u0438 \u0447\u0430\u0441\u0442\u0438\u0447\u043d\u043e \u043f\u0440\u0438 \u0421\u0420\u041a. \u0414\u043e\u0437\u0438\u0440\u043e\u0432\u043a\u0430: 5\u201310 \u0433\/\u0441\u0443\u0442 \u0432 2\u20133 \u043f\u0440\u0438\u0451\u043c\u0430, \u043d\u0430\u0442\u043e\u0449\u0430\u043a. \u041e\u0441\u0442\u043e\u0440\u043e\u0436\u043d\u043e: \u0441\u043f\u043e\u0440\u043d\u044b\u0435 \u0434\u0430\u043d\u043d\u044b\u0435 \u043f\u0440\u0438 \u0421\u0418\u0411\u041e.<\/div><\/details><details style=\"border: 1px solid #CBD5E1; border-radius: 8px; margin-bottom: 8px; overflow: hidden;\"><summary style=\"font-size: 15px; font-weight: bold; color: #1e293b; padding: 14px 18px; cursor: pointer; background: #F8FAFC; list-style: none; display: flex; align-items: center; justify-content: space-between;\">\u041a\u043b\u0430\u0443\u0434\u0438\u043d-2 \u043f\u043e\u0432\u044b\u0448\u0435\u043d \u2014 \u0447\u0442\u043e \u044d\u0442\u043e \u0437\u043d\u0430\u0447\u0438\u0442?<span style=\"font-size: 20px; color: #1e40af; font-weight: 300;\">+<\/span><\/summary><div style=\"padding: 14px 18px 16px; background: #FFFFFF; font-size: 15px; line-height: 1.7; color: #1e293b;\">\u041a\u043b\u0430\u0443\u0434\u0438\u043d-2 \u2014 \u00ab\u043f\u0440\u043e\u0442\u0435\u043a\u0430\u044e\u0449\u0430\u044f\u00bb \u043f\u043e\u0440\u0430. \u0415\u0433\u043e \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u0438\u0435 (\u043d\u0430\u043f\u0440\u0438\u043c\u0435\u0440, \u043f\u043e\u0434 \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435\u043c TNF-\u03b1 \u0438\u043b\u0438 IL-13) \u0441\u043e\u0437\u0434\u0430\u0451\u0442 \u0434\u043e\u043f\u043e\u043b\u043d\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0435 \u043a\u0430\u043d\u0430\u043b\u044b \u0434\u043b\u044f \u0432\u043e\u0434\u044b \u0438 Na\u207a \u2192 \u0434\u0438\u0430\u0440\u0435\u044f \u0438 \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u0430\u044f \u041f\u041a\u041f. \u0410\u0441\u0441\u043e\u0446\u0438\u0438\u0440\u043e\u0432\u0430\u043d \u0441 \u0430\u0442\u043e\u043f\u0438\u0447\u0435\u0441\u043a\u0438\u043c\u0438 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u043c\u0438 \u0438 \u0412\u0417\u041a. \u0421\u043d\u0438\u0436\u0430\u044e\u0442 \u043a\u043b\u0430\u0443\u0434\u0438\u043d-2: Saccharomyces boulardii (\u0434\u043e\u043a\u0430\u0437\u0430\u043d\u043e), \u043f\u0440\u043e\u0442\u0438\u0432\u043e\u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u0430\u044f \u0442\u0435\u0440\u0430\u043f\u0438\u044f (\u0441\u043d\u0438\u0436\u0435\u043d\u0438\u0435 IL-13, TNF-\u03b1).<\/div><\/details><details style=\"border: 1px solid #CBD5E1; border-radius: 8px; margin-bottom: 8px; overflow: hidden;\"><summary style=\"font-size: 15px; font-weight: bold; color: #1e293b; padding: 14px 18px; cursor: pointer; background: #F8FAFC; list-style: none; display: flex; align-items: center; justify-content: space-between;\">\u041c\u043e\u0436\u043d\u043e \u043b\u0438 \u043f\u0440\u043e\u0432\u0435\u0440\u0438\u0442\u044c \u0441\u043e\u0441\u0442\u043e\u044f\u043d\u0438\u0435 tight junctions \u0431\u0435\u0437 \u0431\u0438\u043e\u043f\u0441\u0438\u0438?<span style=\"font-size: 20px; color: #1e40af; font-weight: 300;\">+<\/span><\/summary><div style=\"padding: 14px 18px 16px; background: #FFFFFF; font-size: 15px; line-height: 1.7; color: #1e293b;\">\u0414\u0430 \u2014 \u043a\u043e\u0441\u0432\u0435\u043d\u043d\u043e. \u0417\u043e\u043d\u0443\u043b\u0438\u043d \u0432 \u043a\u0430\u043b\u0435 (\u043e\u0442\u0440\u0430\u0436\u0430\u0435\u0442 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c \u0437\u043e\u043d\u0443\u043b\u0438\u043d-\u0437\u0430\u0432\u0438\u0441\u0438\u043c\u043e\u0433\u043e TJ-\u043e\u0442\u043a\u0440\u044b\u0442\u0438\u044f), L\/M-\u0442\u0435\u0441\u0442 (\u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u0430\u044f \u043e\u0446\u0435\u043d\u043a\u0430 \u043f\u0430\u0440\u0430\u0446\u0435\u043b\u043b\u044e\u043b\u044f\u0440\u043d\u043e\u0433\u043e \u0442\u0440\u0430\u043d\u0437\u0438\u0442\u0430), LBP \u0432 \u043a\u0440\u043e\u0432\u0438 (\u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u044d\u043d\u0434\u043e\u0442\u043e\u043a\u0441\u0435\u043c\u0438\u044f). \u041f\u0440\u044f\u043c\u0430\u044f \u043e\u0446\u0435\u043d\u043a\u0430 TJ-\u0431\u0435\u043b\u043a\u043e\u0432 (ZO-1, \u043e\u043a\u043a\u043b\u044e\u0434\u0438\u043d \u0438\u043c\u043c\u0443\u043d\u043e\u0433\u0438\u0441\u0442\u043e\u0445\u0438\u043c\u0438\u0447\u0435\u0441\u043a\u0438) \u2014 \u0442\u043e\u043b\u044c\u043a\u043e \u0432 \u0431\u0438\u043e\u043f\u0441\u0438\u0438 \u0441\u043b\u0438\u0437\u0438\u0441\u0442\u043e\u0439. \u0414\u043b\u044f \u0440\u0443\u0442\u0438\u043d\u043d\u043e\u0439 \u043f\u0440\u0430\u043a\u0442\u0438\u043a\u0438 \u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e \u0437\u043e\u043d\u0443\u043b\u0438\u043d\u0430 + LBP.<\/div><\/details><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-79f11b7b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"79f11b7b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3888b276\" data-id=\"3888b276\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-732a1e00 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"732a1e00\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t<div class=\"elementor-element elementor-element-76e6395 e-flex e-con-boxed e-con e-parent\" data-id=\"76e6395\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5d42c91 elementor-widget elementor-widget-text-editor\" data-id=\"5d42c91\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center; color: #718096; font-size: 14px;\"><img decoding=\"async\" class=\"emoji\" role=\"img\" draggable=\"false\" src=\"https:\/\/s.w.org\/images\/core\/emoji\/17.0.2\/svg\/1f468-200d-2695-fe0f.svg\" alt=\"\ud83d\udc68\u200d\u2695\ufe0f\" \/> <a href=\"https:\/\/novolakrb1.ru\/o-bolnitse\/meditsinskii-personal\">\u0414\u043e\u043a\u0442\u043e\u0440 \u0421\u0443\u043b\u0435\u0439\u043c\u0430\u043d\u043e\u0432\u0430 \u0411.\u041d.<\/a> | <img decoding=\"async\" class=\"emoji\" role=\"img\" draggable=\"false\" src=\"https:\/\/s.w.org\/images\/core\/emoji\/17.0.2\/svg\/1f4c5.svg\" alt=\"\ud83d\udcc5\" \/> 11.05.2026 | <img decoding=\"async\" class=\"emoji\" role=\"img\" draggable=\"false\" src=\"https:\/\/s.w.org\/images\/core\/emoji\/17.0.2\/svg\/23f1.svg\" alt=\"\u23f1\" \/> 15 \u043c\u0438\u043d \u0447\u0442\u0435\u043d\u0438\u044f<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f35ead8 e-flex e-con-boxed e-con e-parent\" data-id=\"f35ead8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-78cdff6 elementor-widget elementor-widget-html\" data-id=\"78cdff6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<!-- \u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\r\n     \u0411\u041b\u041e\u041a 1 \u00b7 \u041c\u0415\u0414\u0418\u0426\u0418\u041d\u0421\u041a\u0418\u0419 \u0414\u0418\u0421\u041a\u041b\u0415\u0419\u041c\u0415\u0420\r\n     \u0420\u0430\u0437\u043c\u0435\u0449\u0430\u0439\u0442\u0435 \u0432 \u043d\u0430\u0447\u0430\u043b\u0435 \u0438\u043b\u0438 \u043a\u043e\u043d\u0446\u0435 \u043a\u0430\u0436\u0434\u043e\u0439 \u0441\u0442\u0430\u0442\u044c\u0438\r\n     \u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550 -->\r\n\r\n<style>\r\n.mdblog-disclaimer {\r\n  border-left: 4px solid #2a9d8f;\r\n  background: #f0faf9;\r\n  border-radius: 0 8px 8px 0;\r\n  padding: 20px 24px;\r\n  margin: 28px 0;\r\n  font-family: inherit;\r\n  box-sizing: border-box;\r\n}\r\n.mdblog-disclaimer__head {\r\n  display: flex;\r\n  align-items: center;\r\n  gap: 10px;\r\n  margin-bottom: 10px;\r\n}\r\n.mdblog-disclaimer__title {\r\n  font-size: 15px;\r\n  font-weight: 600;\r\n  color: #0f6e56;\r\n  margin: 0;\r\n  line-height: 1.3;\r\n}\r\n.mdblog-disclaimer__text {\r\n  font-size: 14px;\r\n  line-height: 1.7;\r\n  color: #374151;\r\n  margin: 0;\r\n}\r\n.mdblog-disclaimer__text strong {\r\n  font-weight: 600;\r\n  color: #1a5c6b;\r\n}\r\n<\/style>\r\n\r\n<div class=\"mdblog-disclaimer\" role=\"note\" aria-label=\"\u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0434\u0438\u0441\u043a\u043b\u0435\u0439\u043c\u0435\u0440\">\r\n  <div class=\"mdblog-disclaimer__head\">\r\n    <svg width=\"20\" height=\"20\" viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"#2a9d8f\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\">\r\n      <circle cx=\"12\" cy=\"12\" r=\"10\"\/>\r\n      <line x1=\"12\" y1=\"8\" x2=\"12\" y2=\"12\"\/>\r\n      <circle cx=\"12\" cy=\"16\" r=\"0.5\" fill=\"#2a9d8f\"\/>\r\n    <\/svg>\r\n    <p class=\"mdblog-disclaimer__title\">\u0412\u0430\u0436\u043d\u0430\u044f \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f<\/p>\r\n  <\/div>\r\n  <p class=\"mdblog-disclaimer__text\">\r\n    \u041c\u0430\u0442\u0435\u0440\u0438\u0430\u043b\u044b \u044d\u0442\u043e\u0433\u043e \u0431\u043b\u043e\u0433\u0430 \u043d\u043e\u0441\u044f\u0442 <strong>\u0438\u0441\u043a\u043b\u044e\u0447\u0438\u0442\u0435\u043b\u044c\u043d\u043e \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u043e\u043d\u043d\u044b\u0439 \u0438 \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0439 \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440<\/strong> \u0438 \u043d\u0435 \u044f\u0432\u043b\u044f\u044e\u0442\u0441\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e\u0439 \u043a\u043e\u043d\u0441\u0443\u043b\u044c\u0442\u0430\u0446\u0438\u0435\u0439, \u043f\u043e\u0441\u0442\u0430\u043d\u043e\u0432\u043a\u043e\u0439 \u0434\u0438\u0430\u0433\u043d\u043e\u0437\u0430 \u0438\u043b\u0438 \u043d\u0430\u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0435\u043c \u043b\u0435\u0447\u0435\u043d\u0438\u044f. \u0410\u0432\u0442\u043e\u0440 \u2014 \u043f\u0440\u0430\u043a\u0442\u0438\u043a\u0443\u044e\u0449\u0438\u0439 \u0432\u0440\u0430\u0447, \u043e\u0434\u043d\u0430\u043a\u043e \u043f\u0443\u0431\u043b\u0438\u043a\u0443\u0435\u043c\u044b\u0435 \u0441\u0442\u0430\u0442\u044c\u0438 \u043d\u0435 \u0437\u0430\u043c\u0435\u043d\u044f\u044e\u0442 \u0438\u043d\u0434\u0438\u0432\u0438\u0434\u0443\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u043f\u0440\u0438\u0451\u043c\u0430 \u0441\u043f\u0435\u0446\u0438\u0430\u043b\u0438\u0441\u0442\u0430. \u0418\u043d\u0442\u0435\u0440\u043f\u0440\u0435\u0442\u0430\u0446\u0438\u044f \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u044b\u0445 \u043f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u0435\u0439, \u0440\u0435\u0444\u0435\u0440\u0435\u043d\u0441\u043d\u044b\u0445 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0439 \u0438 \u0431\u0438\u043e\u043c\u0430\u0440\u043a\u0435\u0440\u043e\u0432 \u0432\u0441\u0435\u0433\u0434\u0430 \u0434\u043e\u043b\u0436\u043d\u0430 \u043f\u0440\u043e\u0432\u043e\u0434\u0438\u0442\u044c\u0441\u044f \u0432\u0430\u0448\u0438\u043c \u043b\u0435\u0447\u0430\u0449\u0438\u043c \u0432\u0440\u0430\u0447\u043e\u043c \u0441 \u0443\u0447\u0451\u0442\u043e\u043c \u043f\u043e\u043b\u043d\u043e\u0439 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043a\u0430\u0440\u0442\u0438\u043d\u044b. <strong>\u041d\u0435 \u0437\u0430\u043d\u0438\u043c\u0430\u0439\u0442\u0435\u0441\u044c \u0441\u0430\u043c\u043e\u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u043e\u0439 \u0438 \u0441\u0430\u043c\u043e\u043b\u0435\u0447\u0435\u043d\u0438\u0435\u043c.<\/strong>\r\n  <\/p>\r\n<\/div>\r\n\r\n<!-- \u041a\u043e\u043d\u0435\u0446 \u0431\u043b\u043e\u043a\u0430 1 -->\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0cef816 e-flex e-con-boxed e-con e-parent\" data-id=\"0cef816\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b5686b1 elementor-widget elementor-widget-html\" data-id=\"b5686b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<!-- \u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\r\n     \u0411\u041b\u041e\u041a 2 \u00b7 \u041e\u0422\u0421\u0423\u0422\u0421\u0422\u0412\u0418\u0415 \u041a\u041e\u041d\u0424\u041b\u0418\u041a\u0422\u0410 \u0418\u041d\u0422\u0415\u0420\u0415\u0421\u041e\u0412\r\n     \u0420\u0430\u0437\u043c\u0435\u0449\u0430\u0439\u0442\u0435 \u0432 \u043a\u043e\u043d\u0446\u0435 \u0441\u0442\u0430\u0442\u044c\u0438 \u0438\u043b\u0438 \u043d\u0430 \u0441\u0442\u0440\u0430\u043d\u0438\u0446\u0435 \u00ab\u041e\u0431 \u0430\u0432\u0442\u043e\u0440\u0435\u00bb\r\n     \u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550\u2550 -->\r\n\r\n<style>\r\n.mdblog-coi {\r\n  border: 1px solid #d1fae5;\r\n  background: #f0fdf4;\r\n  border-radius: 8px;\r\n  padding: 18px 22px;\r\n  margin: 24px 0;\r\n  font-family: inherit;\r\n  box-sizing: border-box;\r\n}\r\n.mdblog-coi__head {\r\n  display: flex;\r\n  align-items: center;\r\n  gap: 10px;\r\n  margin-bottom: 8px;\r\n}\r\n.mdblog-coi__title {\r\n  font-size: 14px;\r\n  font-weight: 600;\r\n  color: #065f46;\r\n  margin: 0;\r\n  text-transform: uppercase;\r\n  letter-spacing: 0.06em;\r\n}\r\n.mdblog-coi__text {\r\n  font-size: 13.5px;\r\n  line-height: 1.65;\r\n  color: #374151;\r\n  margin: 0;\r\n}\r\n.mdblog-coi__text a {\r\n  color: #0f6e56;\r\n  text-decoration: underline;\r\n  text-underline-offset: 3px;\r\n}\r\n<\/style>\r\n\r\n<div class=\"mdblog-coi\" role=\"note\" aria-label=\"\u041a\u043e\u043d\u0444\u043b\u0438\u043a\u0442 \u0438\u043d\u0442\u0435\u0440\u0435\u0441\u043e\u0432\">\r\n  <div class=\"mdblog-coi__head\">\r\n    <svg width=\"18\" height=\"18\" viewBox=\"0 0 24 24\" fill=\"none\" stroke=\"#059669\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" aria-hidden=\"true\">\r\n      <path d=\"M22 11.08V12a10 10 0 1 1-5.93-9.14\"\/>\r\n      <polyline points=\"22 4 12 14.01 9 11.01\"\/>\r\n    <\/svg>\r\n    <p class=\"mdblog-coi__title\">\u041a\u043e\u043d\u0444\u043b\u0438\u043a\u0442 \u0438\u043d\u0442\u0435\u0440\u0435\u0441\u043e\u0432<\/p>\r\n  <\/div>\r\n  <p class=\"mdblog-coi__text\">\r\n    \u0410\u0432\u0442\u043e\u0440 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